ReviewACS applied materials & interfaces2017
Chemical Functionalization of Plasmonic Surface Biosensors: A Tutorial Review on Issues, Strategies, and Costs.
Review in ACS applied materials & interfaces, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed.
- Surface-Enhanced Raman Spectroscopy for Viral Diagnostics: Principles, Strategies, Clinical Challenges, and Future Directions.Chemical reviews · 2026Review
- Surface Functionalization Studies in the Development of Nanohole Plasmonic Sensors.Sensors (Basel, Switzerland) · 2026Article
- Material-Selective Deposition of Reactive Group-Functionalized Poly‑l‑lysine for DNA Sensing at Optical Waveguides.ACS omega · 2025Article
- Plasmonic Nanosensors for EGFR Detection: Optimizing Aptamer-Based Competitive Displacement Assays.Biosensors · 2025Article
- Carbyne-Enriched Carbon Coatings on Silicon Chips as Biosensing Surfaces with Stable-over-Time Biomolecule Binding Capacity.Nanomaterials (Basel, Switzerland) · 2025Article
- Harnessing the Power of Plasmonics forACS photonics · 2025Review
- Evaluation of Preferential Cytokine Adsorption onto Biosensing Surface Modified with Glycopolymer.Biosensors · 2025Article
- Surface Plasmon Resonance-Based Biodetection Systems: Principles, Progress and Applications-A Comprehensive Review.Biosensors · 2025Review
- Plasmonic biosensors and actuators for integrated point-of-care diagnostics.Npj biosensing · 2025Review
- Plasmonic Coupling for High-Sensitivity Detection of Low Molecular Weight Molecules.Small science · 2025Article
- Active Surface-Enhanced Raman Scattering Platform Based on a 2D Material-Flexible Nanotip Array.Biosensors · 2024Article
- Plasmon-Enhanced Multiphoton Polymer Crosslinking for Selective Modification of Plasmonic Hotspots.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
- Ellman's Assay on the Surface: Thiol Quantification of Human Cofilin-1 Protein through Surface Plasmon Resonance.Langmuir : the ACS journal of surfaces and colloids · 2024Article
- Polarized and Evanescent Guided Wave Surface-Enhanced Raman Spectroscopy of Ligand Interactions on a Plasmonic Nanoparticle Optical Chemical Bench.Biosensors · 2024Article
- Review
- Review
- Plasmonic Fluorescence Sensors in Diagnosis of Infectious Diseases.Biosensors · 2024Review
- Reviewing advances in nanophotonic biosensors.Frontiers in chemistry · 2024Review
- Calligraphy of Nanoplasmonic Bioink-Based Multiplex Immunosensor for Precision Immune Monitoring and Modulation.ACS applied materials & interfaces · 2023Article
- Delocalized Electric Field Enhancement through Near-Infrared Quasi-BIC Modes in a Hollow Cuboid Metasurface.Nanomaterials (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In an ideal plasmonic surface sensor, the bioactive area, where analytes are recognized by specific biomolecules, is surrounded by an area that is generally composed of a different material. The latter, often the surface of the supporting chip, is generally hard to be selectively functionalized, with respect to the active area. As a result, cross talks between the active area and the surrounding one may occur. In designing a plasmonic sensor, various issues must be addressed: the specificity of analyte recognition, the orientation of the immobilized biomolecule that acts as the analyte receptor, and the selectivity of surface coverage. The objective of this tutorial review is to introduce the main rational tools required for a correct and complete approach to chemically functionalize plasmonic surface biosensors. After a short introduction, the review discusses, in detail, the most common strategies for achieving effective surface functionalization. The most important issues, such as the orientation of active molecules and spatial and chemical selectivity, are considered. A list of well-defined protocols is suggested for the most common practical situations. Importantly, for the reported protocols, we also present direct comparisons in term of costs, labor demand, and risk vs benefit balance. In addition, a survey of the most used characterization techniques necessary to validate the chemical protocols is reported.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.