Evidence map›Paper›PMID 28795956›Full record

ReviewExercise and sport sciences reviews2018

Physical Signals May Affect Mesenchymal Stem Cell Differentiation via Epigenetic Controls.

Janet Rubin, Maya Styner, Gunes Uzer

Open access · greenAbstract readReview
In one paragraph

Review in Exercise and sport sciences reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Modeling stem cell nucleus mechanics using confocal microscopy.Biomechanics and modeling in mechanobiology · 2021
    Article
  5. Stem cells and regenerative medicine in sport science.Emerging topics in life sciences · 2021
    Article
  6. Article
  7. Article
  8. Review
  9. Exercise Degrades Bone in Caloric Restriction, Despite Suppression of Marrow Adipose Tissue (MAT).Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2020
    Article
  10. Review
  11. Epigenetics of Skeletal Diseases.Current osteoporosis reports · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Janet RubinDepartment of Medicine, University of North Carolina, Chapel Hill, NC.
Maya StynerDepartment of Medicine, University of North Carolina, Chapel Hill, NC.
Gunes UzerDepartment of Medicine, University of North Carolina, Chapel Hill, NC.
Boise State University · US

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SUSAN M. SMITH · 1999 to 2026
$31.6M
VPS35 D620N inhibits autophagy through disrupted hyaluronic acid-CD44 signalingP20GM109095 · NIGMS · BOISE STATE UNIVERSITY · PI ROMERO, JARED · 2014 to 2023
$22.7M
Mechanical regulation of cytoskeleton guides beta-catenin effect on MSC fateR01AR066616 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBIN, JANET E · 2015 to 2019
$1.7M
Mechanical Control of Mesenchymal Stem Cell Lineage AllocationR01AR056655 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI RUBIN, JANET E · 2010 to 2014
$1.4M
Role of C/EBPbeta in mechanical regulation of MSC potentialK08AR062097 · NIAMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI STYNER, MAYA SHALEV · 2012 to 2016
$651k
NIAMS NIH HHS K08 AR062097NIAMS NIH HHS R01 AR056655NIAMS NIH HHS R01 AR066616NIDDK NIH HHS P30 DK056350NIGMS NIH HHS P20 GM109095
6 · The paper itself

Abstract

Marrow mesenchymal stem cells supply bone osteoblasts and adipocytes. Exercise effects to increase bone and decrease fat involve transfer of signals from the cytoplasm into the nucleus to regulate gene expression. We propose that exercise control of stem cell fate relies on structural connections that terminate in the nucleus and involve intranuclear actin structures that regulate epigenetic gene expression.

Indexed as

Cell DifferentiationEpigenesis, GeneticActinsAdipocytesCytoskeletonExerciseGene ExpressionHumansMesenchymal Stem CellsNuclear MatrixOsteoblastsActins

Identifiers

PMID28795956
PMCPMC5735017
OpenAlexW2743448683

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.