Evidence map›Paper›PMID 28795863›Full record

ArticleTranscription2018

A new era of studying p53-mediated transcription activation.

Wei-Li Liu, Robert A Coleman, Sameer K Singh

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transcription, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Wei-Li Liua Gruss-Lipper Biophotonics Center, Department of Anatomy and Structural Biology , Albert Einstein College of Medicine , Bronx , NY , USA.
Robert A Colemana Gruss-Lipper Biophotonics Center, Department of Anatomy and Structural Biology , Albert Einstein College of Medicine , Bronx , NY , USA.
Sameer K Singha Gruss-Lipper Biophotonics Center, Department of Anatomy and Structural Biology , Albert Einstein College of Medicine , Bronx , NY , USA.
Albert Einstein College of Medicine · US

Funding

Tools For Imaging the Functional Genome in Living Cells and TissuesU01EB021236 · NIBIB · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DARZACQ, XAVIER, SINGER, ROBERT H · 2015 to 2017
$2.5M
NIBIB NIH HHS U01 EB021236
6 · The paper itself

Abstract

To prevent tumorigenesis, p53 stimulates transcription by facilitating the recruitment of the transcription machinery on target gene promoters. Cryo-Electron Microscopy studies on p53-bound RNA Polymerase II (Pol II) reveal that p53 structurally regulates Pol II to affect its DNA binding and elongation, providing new insights into p53-mediated transcriptional regulation.

Indexed as

Transcriptional ActivationCarcinogenesisCryoelectron MicroscopyHumansModels, MolecularPromoter Regions, GeneticProtein BindingProtein ConformationProtein Interaction MapsRNA Polymerase IITumor Suppressor Protein p53RNA Polymerase IITumor Suppressor Protein p533D structurecryo-electron microscopyp53RNA polymerase IItranscription activation

Identifiers

PMID28795863
PMCPMC5834226
OpenAlexW2743465064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.