Evidence map›Paper›PMID 28795366›Full record

ArticleMolecular and cellular biochemistry2018

Ru(II)/diphenylphosphine/pyridine-6-thiolate complexes induce S-180 cell apoptosis through intrinsic mitochondrial pathway involving inhibition of Bcl-2 and p53/Bax activation.

Wanessa Carvalho Pires, Benedicto Augusto Vieira Lima, Flávia de Castro Pereira, Aliny Pereira Lima, Francyelli Mello-Andrade, Hugo Delleon Silva, Monize Martins da Silva, Legna Colina-Vegas, Javier Ellena, Alzir A Batista and 1 more

Open access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Ruthenium (II)/allopurinol complex inhibits breast cancer progression via multiple targets.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Wanessa Carvalho PiresLaboratório de Genética Molecular e Citogenética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, 74690-900, Brazil.
Benedicto Augusto Vieira LimaDepartamento de Química, Universidade Federal de São Carlos, P.O. Box 676, São Carlos, 13565-905, Brazil.
Flávia de Castro PereiraLaboratório de Genética Molecular e Citogenética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, 74690-900, Brazil.
Aliny Pereira LimaLaboratório de Genética Molecular e Citogenética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, 74690-900, Brazil.
Francyelli Mello-AndradeLaboratório de Genética Molecular e Citogenética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, 74690-900, Brazil.
Hugo Delleon SilvaLaboratório de Genética Molecular e Citogenética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, 74690-900, Brazil.
Monize Martins da SilvaDepartamento de Química, Universidade Federal de São Carlos, P.O. Box 676, São Carlos, 13565-905, Brazil.
Legna Colina-VegasDepartamento de Química, Universidade Federal de São Carlos, P.O. Box 676, São Carlos, 13565-905, Brazil.
Javier EllenaInstituto de Física de São Carlos, Universidade de São Paulo, P.O. Box 369, São Carlos, SP, 13560-970, Brazil.
Alzir A BatistaDepartamento de Química, Universidade Federal de São Carlos, P.O. Box 676, São Carlos, 13565-905, Brazil. daab@ufscar.br.
Elisângela de Paul Silveira-LacerdaLaboratório de Genética Molecular e Citogenética, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Goiânia, GO, 74690-900, Brazil. elacerda@ufg.br.ORCID http://orcid.org/0000-0002-4143-9007
Universidade Federal de Goiás · BRUniversidade Federal de São Carlos · BRUniversidade de São Paulo · BR

Funding

Financiadora de Estudos e Projetos 01.06.0941.00/CT-SaúdeFundação de Amparo à Pesquisa do Estado de São Paulo 2014/10516-7
6 · The paper itself

Abstract

The aim of this work was the synthesis, characterization, and cytotoxicity evaluation of three new Ru(II) complexes with a general formula [Ru(Spy)(bipy)(P-P)]PF

Indexed as

Coordination ComplexesRutheniumAnimalsApoptosisbcl-2-Associated X ProteinHumansK562 CellsMiceMitochondriaProto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53Bax protein, mousebcl-2-Associated X ProteinBcl2 protein, mouseCoordination ComplexesProto-Oncogene Proteins c-bcl-2RutheniumTumor Suppressor Protein p53ApoptosisDiphenylphosphinePyridine-6-thiolateRu(II) complexesSarcoma-180

Identifiers

PMID28795366
OpenAlexW2743454771

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.