Evidence map›Paper›PMID 28795332›Full record

ArticleAdvances in therapy2017

The Patterns of Non-vitamin K Antagonist Oral Anticoagulants (NOACs) Use in Patients with Atrial Fibrillation in Seven Balkan Countries: a Report from the BALKAN-AF Survey.

Tatjana S Potpara, Elina Trendafilova, Gheorghe-Andrei Dan, Artan Goda, Zumreta Kusljugic, Sime Manola, Ljilja Music, Viktor Gjini, Belma Pojskic, Mircea Ioakim Popescu and 11 more

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In one paragraph

Article in Advances in therapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

21 authors.

Tatjana S PotparaSchool of Medicine, Belgrade University, Belgrade, Serbia. tatjana.potpara@med.bg.ac.rs.
Elina TrendafilovaNational Heart Hospital, Sofia, Bulgaria.
Gheorghe-Andrei DanMedicine University "Carol Davila", Colentina University Hospital, Bucharest, Romania.
Artan GodaClinic of Cardiology, University Hospital Centre Mother Theresa, Tirana, Albania.
Zumreta KusljugicCardiology Department, Clinic for Internal Diseases, Tuzla, Bosnia and Herzegovina.
Sime ManolaClinical Hospital Centre Sestre Milosrdnice, Zagreb, Croatia.
Ljilja MusicUniversity Clinical Centre Podgorica, Podgorica, Montenegro.
Viktor GjiniRegional Hospital, Fier, Albania.
Belma PojskicGeneral Hospital Zenica, Zenica, Bosnia and Herzegovina.
Mircea Ioakim PopescuCardiology Department, Emergency Hospital, Oradea, Romania.
Catalina Arsenescu GeorgescuInsitute for Cardiovascular Diseases 'Prof Dr George I.M. Georgescu', Iasi, Romania.
Elena S DimitrovaMedicine University "Carol Davila", Colentina University Hospital, Bucharest, Romania.
Delyana KamenovaHealth Centre Vidin, Vidin, Bulgaria.
Uliks EkmeciuClinic of Cardiology, University Hospital Centre Mother Theresa, Tirana, Albania.
Denis MrsicCardiology Department, Clinic for Internal Diseases, Tuzla, Bosnia and Herzegovina.
Ana NenezicUniversity Clinical Centre Podgorica, Podgorica, Montenegro.
Sandro BrusichClinical Hospital Centre Rijeka, Rijeka, Croatia.
Srdjan MilanovClinical Centre Kragujevac, Kragujevac, Serbia.
Ivan ZeljkovicClinical Hospital Centre Sestre Milosrdnice, Zagreb, Croatia.
Gregory Y H LipSchool of Medicine, Belgrade University, Belgrade, Serbia.
BALKAN-AF Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionData on management of atrial fibrillation (AF) in the Balkan Region are scarce. To capture the patterns in AF management in contemporary clinical practice in the Balkan countries a prospective survey was conducted between December 2014 and February 2015, and we report results pertinent to the use of non-vitamin K antagonist oral anticoagulants (NOACs).

methodsA 14-week prospective, multicenter survey of consecutive AF patients seen by cardiologists or internal medicine specialists was conducted in Albania, Bosnia and Herzegovina, Bulgaria, Croatia, Montenegro, Romania, and Serbia (a total of about 50 million inhabitants).

resultsOf 2712 enrolled patients, 2663 (98.2%) had complete data relevant to oral anticoagulant (OAC) use (mean age 69.1 ± 10.9 years, female 44.6%). Overall, OAC was used in 1960 patients (73.6%) of whom 338 (17.2%) received NOACs. Malignancy [odds ratio (OR), 95% confidence interval (CI) 2.06, 1.20-3.56], rhythm control (OR 1.64, 1.25-2.16), and treatment by cardiologists were independent predictors of NOAC use (OR 2.32, 1.51-3.54) [all p < 0.01)], whilst heart failure and valvular disease were negatively associated with NOAC use (both p < 0.01). Individual stroke and bleeding risk were not significantly associated with NOAC use on multivariate analysis.

conclusionsNOACs are increasingly used in AF patients in the Balkan Region, but NOAC use is predominantly guided by factors other than evidence-based decision-making (e.g., drug availability on the market or reimbursement policy). Efforts are needed to establish an evidence-based approach to OAC selection and to facilitate the optimal use of OAC, thus improving the outcomes in AF patients in this large region.

Indexed as

Administration, OralAgedAged, 80 and overAnticoagulantsAtrial FibrillationBalkan PeninsulaFemaleHumansMiddle AgedProspective StudiesRisk FactorsStrokeSurveys and QuestionnairesVitamin KAnticoagulantsVitamin KAdherence to guidelinesAtrial fibrillationBalkan RegionBleeding riskClinical practiceEvidence-based approachGeneral cardiologyOral anticoagulationStroke preventionStroke risk

Identifiers

PMID28795332
PMCPMC5565662

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.