ArticleThe Biochemical journal1986
Differential tissue expression of the glutathione transferase multigene family.
Article in The Biochemical journal, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Purification and kinetic mechanism of the major glutathione S-transferase from bovine brain.The Biochemical journal · 1989Article
- The separation of glutathione transferase subunits by using reverse-phase high-pressure liquid chromatography.The Biochemical journal · 1987Article
- Tissue distribution of rat glutathione transferase subunit 7, a hepatoma marker.The Biochemical journal · 1986Article
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4 authors.
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Abstract
The content of GSH transferase mRNAs in poly(A)-containing RNA isolated from eight rat tissues was examined by immunoprecipitation of cell-free translation products and by Northern blotting. Considerable tissue-specific distribution and heterogeneity of immunoprecipitable GSH transferase subunits 1 and 2 synthesized in vitro was observed. These results were confirmed by Northern blotting using a 32P-labelled subunit 1 cDNA probe. The same probe, used in a Southern blot analysis of genomic DNA, provided confirmation that GSH transferase subunits 1 and 2 comprise a multigenic family in the rat. The results show that the selection of cDNA clones coding for chosen subunits can be made easier by making use of qualitative and quantitative tissue differences in GSH transferase mRNAs.
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