Evidence map›Paper›PMID 28795317›Full record

ArticleMycopathologia2017

Nonsteroidal Anti-inflammatory Drugs (NSAIDS) Inhibit the Growth and Reproduction of Chaetomium globosum and Other Fungi Associated with Water-Damaged Buildings.

Kelsey Dalmont, Charles L Biles, Heather Konsure, Sujita Dahal, Tyler Rowsey, Matthew Broge, Shubhra Poudyal, Tara Gurung, Sabina Shrestha, Caleb L Biles and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Mycopathologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Kelsey DalmontCollege of Osteopathic Medicine, Oklahoma State University, 1111 West 17th Street, Tulsa, OK, 74107, USA.
Charles L BilesDepartment of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA. cbiles@ecok.edu.
Heather KonsureCollege of Osteopathic Medicine, Oklahoma State University, 1111 West 17th Street, Tulsa, OK, 74107, USA.
Sujita DahalDepartment of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA.
Tyler RowseyDepartment of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA.
Matthew BrogeDepartment of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA.
Shubhra PoudyalDepartment of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA.
Tara GurungDepartment of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA.
Sabina ShresthaDepartment of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA.
Caleb L BilesDepartment of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA.
Terry CluckDepartment of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA.
Alisha HowardDepartment of Biology, East Central University, 1100 East 14th Street, Box N-5, Ada, OK, 74820, USA.
East Central University · USOklahoma State University Medical Center · US

Funding

McNair Scholars Program at East Central University Department of Education award P217A120030National Center for Research Resources and the National Institute of General Medical Sciences of the National Institutes of Health Grant number 8P20GM103447 (OK-INBRE)National Institutes of Health-Bridges to the Baccalaureate program at East Central University R25 GM054938-07
6 · The paper itself

Abstract

Indoor mold due to water damage causes serious human respiratory disorders, and the remediation to homes, schools, and businesses is a major expense. Prevention of mold infestation of building materials would reduce health problems and building remediation costs. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit yeasts and a limited number of filamentous fungi. The purpose of this research was to determine the possible inhibitory activity of nonsteroidal anti-inflammatory drugs (NSAIDs) on germination, fungal growth, and reproduction of Chaetomium globosum and other important filamentous fungi that occur in water-damaged buildings. Several NSAIDs were found to inhibit C. globosum germination, growth, and reproduction. The most effective NSAIDs inhibiting C. globosum were ibuprofen, diflunisal, and diclofenac. Fusarium oxysporum, Fusarium solani, Aspergillus niger, and Stachybotrys atra were also tested on the various media with similar results obtained. However, F. oxysporum and A. niger exhibited a higher level of resistance to aspirin and NaSAL when compared to the C. globosum isolates. The inhibition exhibited by NSAIDs was variable depending on growth media and stage of fungal development. These compounds have a great potential of inhibiting fungal growth on building materials such as gypsum board. Formulations of sprays or building materials with NSAID-like chemical treatments may hold promise in reducing mold in homes and buildings.

Indexed as

AcetaminophenAntifungal AgentsAnti-Inflammatory Agents, Non-SteroidalAspergillusAspirinCell ProliferationChaetomiumDiclofenacDiflunisalFusariumGerminationHumansIbuprofenLung Diseases, FungalMicrobial Sensitivity TestsMycosesAcetaminophenAntifungal AgentsAnti-Inflammatory Agents, Non-SteroidalAspirinDiclofenacDiflunisalIbuprofenAcetaminophenAspergillus nigerChaetomium sp.Fungal inhibitionFusarium oxysporumFusarium solaniHyphal growthMoldNSAIDsPerithecia synthesisSpore germinationStachybotrys atraWater-damaged buildings

Identifiers

PMID28795317
OpenAlexW2742735121

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.