Evidence map›Paper›PMID 28795292›Full record

ReviewCurrent allergy and asthma reports2017

Relevance of Lipophilic Allergens in Food Allergy Diagnosis.

Uta Jappe, Christian Schwager

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current allergy and asthma reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Advancing allergen characterization in Perilla seed: an oil body purification approach.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung · 2022
    Review
  8. Oleosin Cor a 15 is a novel allergen for Italian hazelnut allergic children.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2021
    Article
  9. Article
  10. Article
  11. Recent advances in the management of nut allergy.The World Allergy Organization journal · 2021
    Review
  12. Review
  13. Review
  14. A WAO - ARIA - GAThe World Allergy Organization journal · 2020
    Article
  15. Review
  16. Review
  17. Review
  18. Allergen Extracts for In Vivo Diagnosis and Treatment of Allergy: Is There a Future?The journal of allergy and clinical immunology. In practice
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Uta JappeDivision of Clinical and Molecular Allergology, Priority Research Area Asthma & Allergy, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Research Center Borstel, Parkallee 35, 23845, Borstel, Germany. ujappe@fz-borstel.de.
Christian SchwagerDivision of Clinical and Molecular Allergology, Priority Research Area Asthma & Allergy, Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL), Research Center Borstel, Parkallee 35, 23845, Borstel, Germany.
German Center for Lung Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewThe purpose of this review is to provide available data on a new class of allergens, the oleosins, and their diagnostic value. There is evidence that allergen extracts used for in vivo as well as in vitro diagnostic tests do not contain oleosins because these proteins are lipophilic and nearly insoluble in saline or aqueous solutions. So far, only oleosins of peanut, sesame and hazelnut have been registered as allergens. Reports on IgE-binding tests performed with oleosins of different species with sera from allergic patients show that IgE specific for oleosins are associated with severe allergic reactions which is why they should be part of the diagnostic tests in the future. RECENT

findingsRecent findings showed that oleosins purified from in shell-roasted peanuts revealed a higher IgE-binding capacity when compared to raw ones. Naturally purified as well as recombinantly produced peanut oleosins can be used in basophil activation test. The synopsis of all reports on different thermal processing of several oleosin sources and the respective data obtained with patients sera investigated via immunoblot and basophil activation test points to the recommendation that-if naturally purified oleosins are used, they should mostly be obtained from roasted food allergen sources. For immunoblot and basophil activation test, both, naturally purified oleosins as well as recombinant modified oleosins are valuable diagnostic tools.

Indexed as

AllergensBasophilsFood HypersensitivityHumansHydrophobic and Hydrophilic InteractionsImmunoglobulin EPlant ProteinsProtein BindingQuality ImprovementReagent Kits, DiagnosticAllergensImmunoglobulin EPlant ProteinsReagent Kits, DiagnosticFood allergyLipophilic allergensMarker allergensOil bodyOil seedsOleosinPeanut allergyPrecision medicineSingle allergens

Identifiers

PMID28795292
OpenAlexW2744924949

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.