ArticleChronic stress (Thousand Oaks, Calif.)2017
Chronic Pain and Chronic Stress: Two Sides of the Same Coin?
Article in Chronic stress (Thousand Oaks, Calif.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07036354 (Evaluation of the Effects of Human-Animal Interaction on Physiological and Psychological Anxiety Markers in Graduate Students), which is not on this map. Cited by 168 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effects of Human-Animal Interaction on Physiological and Psychological Anxiety Markers in Graduate Students
Who cites it
168 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Physiological Responses to Virtual Reality-Based Stress Regulation and Relaxation Interventions: A Systematic Review.Stress and health : journal of the International Society for the Investigation of Stress · 2026Pooled it
- Pain and mild cognitive impairment among adults aged 50 years and above residing in low- and middle-income countries.Aging clinical and experimental research · 2023Pooled it
- The Effect of Occupational Engagement on Lifestyle in Adults Living with Chronic Pain: A Systematic Review and Meta-analysis.Occupational therapy international · 2022Pooled it
- The medial temporal lobe in nociception: a meta-analytic and functional connectivity study.Pain · 2019Pooled it
- Transcranial Direct Current Stimulation to Improve the Dysfunction of Descending Pain Modulatory System Related to Opioids in Chronic Non-cancer Pain: An Integrative Review of Neurobiology and Meta-Analysis.Frontiers in neuroscience · 2019Pooled it
- Telephone-based aftercare groups for family carers of people with dementia - results of the effect evaluation of a randomised controlled trial.BMC health services research · 2022Trial
- Flotation Restricted Environmental Stimulation Therapy for Chronic Pain: A Randomized Clinical Trial.JAMA network open · 2021Trial
- Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026Review
- Reflections on 20 Years of Research on Tai Chi for Chronic Musculoskeletal Pain: An Updated Review.Current rheumatology reports · 2026Review
- Investigating associations between allostatic load phenotypes and clinical impairment in youth with chronic pain.Brain, behavior, & immunity - health · 2026Article
- Antagonizing the corticotropin-releasing hormone receptor 1 with an orally bioavailable drug reduces endometriosis pain and associated adhesions†.Biology of reproduction · 2026Article
- Structural and individualized racism drives racial disparities in chronic low back pain: A cross-sectional serial mediation analysis.The journal of pain · 2026Article
- Review
- Short Cationic ACTH-Related Peptides Can Modulate the NaInternational journal of molecular sciences · 2026Article
- Pain Prevalence and Intensity Among Older Family Caregivers Versus Non-Caregivers in the United States.Journal of aging and health · 2026Article
- Impact of adverse life experiences on pain, depression, anxiety, and comorbidities: a youth longitudinal sample.Pain reports · 2026Article
- Review
- Article
- Cerebellar Tissue Properties Alterations in Fibromyalgia: A T1w/T2w Ratio Study.Human brain mapping · 2026Article
- Stress-related white matter microstructure alterations and chronic pain.Brain imaging and behavior · 2026Article
108 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Pain and stress share significant conceptual and physiological overlaps. Both phenomena challenge the body's homeostasis and necessitate decision-making to help animals adapt to their environment. In addition, chronic stress and chronic pain share a common behavioral model of failure to extinguish negative memories. Yet, they also have discrepancies such that the final brain endophenotype of posttraumatic stress disorder, depression, and chronic pain appears to be different among the three conditions, and the role of the hypothalamic-pituitary-adrenal axis remains unclear in the physiology of pain. Persistence of either stress or pain is maladaptive and could lead to compromised well-being. In this brief review, we highlight the commonalities and differences between chronic stress and chronic pain, while focusing particularly on the central role of the limbic brain. We assess the current attempts in the field to conceptualize and understand chronic pain, within the context of knowledge gained from the stress literature. The limbic brain-including hippocampus, amygdala, and ventromedial pre-frontal cortex-plays a critical role in learning. These brain areas integrate incoming nociceptive or stress signals with internal state, and generate learning signals necessary for decision-making. Therefore, the physiological and structural remodeling of this learning circuitry is observed in conditions such as chronic pain, depression, and posttraumatic stress disorder, and is also linked to the risk of onset of these conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.