ELECTRICAL INSTABILITY DUE TO REGIONAL INCREASE IN EXTRACELLULAR POTASSIUM ION CONCENTRATION.

Sunil M Kandel, Bradley J Roth

Open access · greenAbstract read

In one paragraph

Article in Journal of nature and science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 89% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Sunil M KandelDepartment of Physics, Oakland University, Rochester, Michigan.

Bradley J RothDepartment of Physics, Oakland University, Rochester, Michigan.

Oakland University · US

Funding

Optimal design of challenge-response experiments in cardiac electrophysiologyR01HL118392 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHOTWELL, MATTHEW STEPHEN · 2013 to 2016

$1.5M

NHLBI NIH HHS R01 HL118392

6 · The paper itself

Abstract

introductionVentricular tachycardia and ventricular fibrillation are the two most dangerous arrhythmias. Both are related to reentrant electrical activity in the ventricles. Many studies of arrhythmias consider a homogeneous sheet of cardiac tissue. Since normal ventricular myocardium is inhomogeneous and inhomogeneities play an important role in the induction of reentry, we investigate the effect of a localized inhomogeniety developed at the border between normal and ischemic region.

methodsWe used the bidomain model to represent the electrical properties of cardiac tissue and a modified version of the dynamic Luo-Rudy (LRd) model to represent the active properties of the membrane. To investigate the effect of a localized inhomogeneity, the extracellular potassium [K] RESULTS AND DISCUSSION: A train of cathodal stimuli are applied from the lower left corner of the tissue with different basic cycle lengths (BCL). At certain BCL, the spatial heterogeneity created with regional elevation of [K]

conclusionElectrical alternans occur during high heart rates and are observed in patients suffering from ventricular tachycardia. It is an early indication of left ventricular systolic impairment. This study will help to evaluate alternans as a predictor and guide for antiarrhythmic therapy.

Indexed as

alternansArrhythmiasbidomain modelLuo-Rudy Model

Identifiers

PMID28795153

PMCPMC5546303

OpenAlexW2188185899

What OpenQuestion holds

Textmetadata

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.