ArticleClinical and experimental reproductive medicine2017
Evaluation of sperm protamine deficiency and apoptosis in infertile men with idiopathic teratozoospermia.
Article in Clinical and experimental reproductive medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- The impact of mitochondrial impairments on sperm function and male fertility: a systematic review.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- The use of birefringence for human spermatozoa selection before intracytoplasmic sperm injection to improve artificial reproductive technology outcomes: A systematic review and meta-analysis.Clinical and experimental reproductive medicine · 2026Article
- Integrative functional and molecular characterization of Bali bull semen and its relationship with reproductive performance.Veterinary world · 2026Article
- Predictors of elevated sperm DNA fragmentation: a morphology-based approach to semen analysis.Basic and clinical andrology · 2025Article
- Differential significance of Seminal Cell-Free DNA Levels, Oxidative Stress, and Sperm Characteristic between Infertile Men with Non-obstructive and obstructive Azoospermia.JBRA assisted reproduction · 2025Article
- The Relationship Between Sperm Midpiece Details and DNA Fragmentation in Human Sperm.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- L-Carnitine and Acetyl-L-Carnitine: A Novel Approach to Treating Male Infertility with Abnormal Sperm Morphology.Journal of pharmacy & bioallied sciences · 2025Article
- Detrimental impact of cell phone radiation on sperm DNA integrity.Clinical and experimental reproductive medicine · 2024Article
- Possible Harmful Effects of Smoking Hookah on Sperm DNA Fragmentation Index and Protamine Genes Expression in Normozoospermic Men.Substance abuse : research and treatment · 2023Article
- Relationship between sperm morphology and sperm DNA dispersion.Translational andrology and urology · 2020Article
- Article
- Analysis of PRM1 and PRM2 Polymorphisms in Iranian Infertile Men with Idiopathic Teratozoospermia.International journal of fertility & sterility · 2019Article
- Biallelic mutations inAsian journal of andrologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSperm morphology plays an important role in infertility, especially in cases of defects in the heads of spermatozoa. Tapered-head or elongated-head spermatozoa are examples of morphological abnormalities. The aim of this study was to compare the semen parameters, levels of protamine deficiency, and frequency of apoptosis between patients with normozoospermia and those with teratozoospermia with tapered-head spermatozoa.
methodsFifty-two semen samples (27 patients with tapered-head sperm and 25 fertile men) were collected and semen analysis was performed according to the World Health Organization criteria for each sample. Protamine deficiency and the percentage of apoptotic spermatozoa were evaluated using chromomycin A3 (CMA3) staining and terminal deoxynucleotidyl transferase dUTP nick-end labelling (TUNEL) assays, respectively.
resultsSperm concentration, motility, and normal morphology in the tapered-head spermatozoa (cases) were significantly lower than in the normozoospermic samples (controls). CMA3-reactive spermatozoa (CMA3+) in the case group were more common than in the controls. Apoptotic spermatozoa (TUNEL-positive) were significantly more common in the cases than in the controls.
conclusionThis analysis showed that tapered-head spermatozoa contained abnormal chromatin packaging and exhibited a high rate of apoptosis, which can be considered to be an important reason for the impaired fertility potential in teratozoospermic patients with tapered-head spermatozoa.
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