ArticleNeuroImage. Clinical2017
A test-retest study on Parkinson's PPMI dataset yields statistically significant white matter fascicles.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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87 citing papers in PubMed, 165 citations in OpenAlex.
- Objective characterization of displacement of the frontal aslant tract in low-grade glioma: a quantitative tractography study.Neuroradiology · 2026Article
- Loss of Neocortical Oligodendrocytes in Parkinson's Disease Patients-A Stereological Study.Journal of neuroscience research · 2026Article
- The microstructure-weighted human connectome: network properties and structure-function correlations across spatial scales.bioRxiv : the preprint server for biology · 2026Article
- Bridging Histology and Tractography: First In Vivo Visualization of Short-Range Prefrontal Connections Informed by Primate Tract-Tracing.Human brain mapping · 2026Article
- Longitudinal visualization tools for advanced characterization of multiple sclerosis lesions using diffusion MRI and magnetization transfer imaging metrics.Brain structure & function · 2026Article
- White Matter Bundle Reconstruction From Single-Shell Diffusion Magnetic Resonance Imaging: Test-Retest Reliability and Predictive Capability Across Orientation Distribution Function Reconstruction Methods.Human brain mapping · 2025Article
- Effect of a consistent reconstruction algorithm on inter-scanner reproducibility in diffusion MRI.Medical physics · 2025Article
- Bridging Histology and Tractography: First Visualization of the Short-Range Prefrontal Connections in the Human Brain.bioRxiv : the preprint server for biology · 2025Article
- Accelerated multi-shell diffusion MRI with Gaussian process estimated reconstruction of multi-band imaging.Magnetic resonance in medicine · 2025Article
- Rethinking MRI as a measurement device through modular and portable pipelines.Magma (New York, N.Y.) · 2025Review
- Mapping Caudolenticular Gray Matter Bridges in the Human Brain Striatum Through Diffusion Magnetic Resonance Imaging and Tractography.Human brain mapping · 2025Article
- White Matter Fiber Bundle Alterations Correlate with Gait and Cognitive Impairments in Parkinson’s Disease based on HARDI DataCurrent medical imaging · 2025Article
- Longitudinal reproducibility of brain and spinal cord quantitative MRI biomarkers.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Exploring the Relationship Between White Matter Tracts and Resting-State Functional Language Lateralization Index.Neurobiology of language (Cambridge, Mass.) · 2025Article
- Structural Connectivity of the Basal Ganglia from Patient-Individual Tractography Is Key for Understanding the Effects of Deep Brain Stimulation in Parkinson's Disease.Stereotactic and functional neurosurgery · 2025Article
- Scalable quality control on processing of large diffusion-weighted and structural magnetic resonance imaging datasets.PloS one · 2025Article
- Free water elimination tractometry for aging brains.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Tractography-Based Automated Identification of Retinogeniculate Visual Pathway With Novel Microstructure-Informed Supervised Contrastive Learning.Human brain mapping · 2024Article
- Atrophy-related corticospinal changes in advanced Parkinson's disease are associated with the genetic etiology of the disease.Journal of Parkinson's disease · 2024Article
- A worldwide study of white matter microstructural alterations in people living with Parkinson's disease.NPJ Parkinson's disease · 2024Article
27 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, we propose a diffusion MRI protocol for mining Parkinson's disease diffusion MRI datasets and recover robust disease-specific biomarkers. Using advanced high angular resolution diffusion imaging (HARDI) crossing fiber modeling and tractography robust to partial volume effects, we automatically dissected 50 white matter (WM) fascicles. These fascicles connect deep nuclei (thalamus, putamen, pallidum) to different cortical functional areas (associative, motor, sensorimotor, limbic), basal forebrain and substantia nigra. Then, among these 50 candidate WM fascicles, only the ones that passed a test-retest reproducibility procedure qualified for further tractometry analysis. Leveraging the unique 2-timepoints test-retest Parkinson's Progression Markers Initiative (PPMI) dataset of over 600 subjects, we found statistically significant differences in tract profiles along the subcortico-cortical pathways between Parkinson's disease patients and healthy controls. In particular, significant increases in FA, apparent fiber density, tract-density and generalized FA were detected in some locations of the nigro-subthalamo-putaminal-thalamo-cortical pathway. This connection is one of the major motor circuits balancing the coordination of motor output. Detailed and quantifiable knowledge on WM fascicles in these areas is thus essential to improve the quality and outcome of Deep Brain Stimulation, and to target new WM locations for investigation.
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