ArticleNeuroImage. Clinical2017
Fractional amplitude of low-frequency fluctuations (fALFF) in post-stroke depression.
Article in NeuroImage. Clinical, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
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Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Spontaneous Brain Activity Alterations in First-Episode Psychosis: A Meta-analysis of Functional Magnetic Resonance Imaging Studies.Schizophrenia bulletin · 2023Pooled it
- Frequency-dependent alterations of degree centrality in patients with poststroke depression: a resting-state functional MRI study.Neuroreport · 2026Article
- Age-Related Low Frequency Amplitude Differences in Resting-State Blood Oxygenation Level-Dependent Signal in the Cerebellum.Human brain mapping · 2026Article
- The Cerebrovascular Reactivity Adjusted Fractional Amplitude of Low-Frequency Fluctuations Abnormalities in Middle Cerebral Artery Stenosis and Occlusive Disease.Translational stroke research · 2026Article
- Revisiting Amplitude of Low-Frequency Fluctuations (ALFF) in Resting-State fMRI: Clarifications and Improvements.Human brain mapping · 2026Article
- Distributed fMRI Patterns Coupled to Low-Frequency Cardiorespiratory Dynamics Provide Markers of Aging.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Machine learning combined with resting-state functional MRI to characterize functional brain differences in post-stroke depression.Frontiers in psychiatry · 2026Article
- Detecting altered spontaneous activities of different brain areas in diabetic vitreous hemorrhage patients: a magnetic resonance imaging study.International journal of ophthalmology · 2026Article
- Distributed fMRI patterns coupled to low-frequency cardiorespiratory dynamics provide markers of aging.bioRxiv : the preprint server for biology · 2025Article
- Altered spontaneous neural activity and its association with cognition, abdominal fat and liver function in children with obesity.Pediatric research · 2025Article
- The relationship between fractional amplitude of low-frequency fluctuations (fALFF) and the severity of neglect in patients with unilateral spatial neglect (USN) after stroke: A functional near-infrared spectroscopy study.IBRO neuroscience reports · 2025Article
- Research Advances in Multimodal Framework-Based Identification and Therapeutic Management of Post-Stroke Depression via the Microbiota-Gut-Brain Axis.Neuropsychiatric disease and treatment · 2025Review
- Associations of alcohol and tobacco use with psychotic, depressive and developmental disorders revealed via multimodal neuroimaging.Translational psychiatry · 2024Article
- Abnormal intrinsic functional hubs and connectivity in patients with post-stroke depression.Annals of clinical and translational neurology · 2024Article
- Post-Stroke Depression in Older Adults: An Overview.Drugs & aging · 2024Review
- Frequency specific alterations of the degree centrality in patients with acute basal ganglia ischemic stroke: a resting-state fMRI study.Brain imaging and behavior · 2024Article
- Fractional amplitude of low-frequency fluctuations during music-evoked autobiographical memories in neurotypical older adults.Frontiers in neuroscience · 2024Article
- Voxel-wise Fusion of Resting fMRI Networks and Gray Matter Volume for Alzheimer's Disease Classification using Deep Multimodal Learning.Research square · 2023Article
- fMRI fluctuations within the language network are correlated with severity of hallucinatory symptoms in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Alterations in resting-state functional activity and connectivity for major depressive disorder appetite and weight disturbance phenotypes.Psychological medicine · 2023Article
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression is a common outcome following stroke, associated with reduced quality of life and poorer recovery. Despite attempts to associate depression symptoms with specific lesion sites, the neural basis of post-stroke depression remains poorly understood. Resting state fMRI has provided new insights into the neural underpinnings of post-stroke depression, but has been limited to connectivity analyses exploring interregional correlations in the time-course of activity. Other aspects of resting state BOLD signal remain unexamined. Measuring the amplitude of low frequency fluctuations allows the detection of spontaneous neural activity across the whole brain. It provides complementary information about frequency-specific local neural activity. We calculated the fractional amplitude of low frequency fluctuations (fALFF) in a group of 64 participants scanned 3 months post-stroke. Twenty showed depression symptoms when assessed with the Patient Health Questionnaire (PHQ-9). We performed analyses in both the typical 0.01-0.08 Hz range, as well as separately in the slow-5 (0.01-0.027 Hz) and slow-4 (0.027-0.073 Hz) ranges. We found significantly higher fALFF in the depressed compared to non-depressed participants in the left dorsolateral prefrontal cortex (DLPFC) and the right precentral gyrus, and a significant association between higher depression scores and higher fALFF in the left insula. The group differences were detected in the slow-5 fluctuations, while the association with depression severity was observed in the slow-4 range. We conclude that post-stroke depression can be characterised by aberrant spontaneous local neural activity, which in small samples could be a more sensitive measure than lesion volume and location.
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