ArticleBJPsych open2017
Prevalence of and associations with agitation in residents with dementia living in care homes: MARQUE cross-sectional study.
Article in BJPsych open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Dose-Dependent efficacy and safety of Brexpiprazole in agitation associated with dementia in Alzheimer's disease: A systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Detecting agitation and aggression in persons living with dementia: a systematic review of diagnostic accuracy.BMC geriatrics · 2024Pooled it
- Interventions promoting family involvement with care homes following placement of a relative with dementia: A systematic review.Dementia (London, England) · 2022Pooled it
- Efficacy of Brexpiprazole on Neuropsychiatric Symptoms and Impact on Caregivers: Pooled Neuropsychiatric Inventory (NPI) Analysis in Patients With Agitation Associated With Dementia due to Alzheimer's Disease.Journal of geriatric psychiatry and neurology · 2026Trial
- Brexpiprazole for agitation in clinically relevant patient subgroups: aCurrent medical research and opinion · 2025Trial
- Using Structured Observations to Evaluate the Effects of a Personalized Music Intervention on Agitated Behaviors and Mood in Nursing Home Residents With Dementia: Results From an Embedded, Pragmatic Randomized Controlled Trial.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2024Trial
- Factor Analysis of the Short-Form Cohen-Mansfield Agitation Inventory and the Measurement Invariance by Gender.Journal of nursing measurement · 2021Trial
- Cost-Effectiveness of Dementia Care Mapping in Care-Home Settings: Evaluation of a Randomised Controlled Trial.Applied health economics and health policy · 2020Trial
- Trial
- Observational
- Insights on Recruitment, Implementation, and Movement Pattern Detection by Exploring the Feasibility of Sensor-Based Insole Technology in Long-Term Care: Mixed Methods Feasibility Study.JMIR formative research · 2026Article
- The Use of Equine-Assisted Therapy in Patients With Aggression and Agitation Behaviors due to Moderate-to-Severe Dementia: A Case Series.Case reports in psychiatry · 2025Article
- Social connection in long-term care homes: a qualitative study of barriers and facilitators.BMC geriatrics · 2024Article
- Organizational characteristics of highly specialized units for people with dementia and severe challenging behavior.BMC geriatrics · 2024Article
- Wrist-worn actigraphy in agitated late-stage dementia patients: A feasibility study on digital inclusion.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- We know the skills doctors need to work with care home residents: now we need to think about how to deliver them.The British journal of general practice : the journal of the Royal College of General Practitioners · 2024Article
- A Confirmatory and an Exploratory Factor Analysis of the Cohen-Mansfield Agitation Inventory (CMAI) in a European Case Series of Patients with Dementia: Results from the RECage Study.Brain sciences · 2023Article
- Agitation and aggression in people living with dementia and mild cognitive impairment in shared-housing arrangements - validation of a German version of the Cohen-Mansfield Agitation Inventory-Short Form (CMAI-SF).Health and quality of life outcomes · 2023Article
- Antidepressant medications in dementia: evidence and potential mechanisms of treatment-resistance.Psychological medicine · 2023Review
- Care home residents with dementia: Prevalence, incidence, and associations with sleep disturbance in an English cohort study.Alzheimer's & dementia (New York, N. Y.) · 2022Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAgitation is reportedly the most common neuropsychiatric symptom in care home residents with dementia.
aimsTo report, in a large care home survey, prevalence and determinants of agitation in residents with dementia.
methodWe interviewed staff from 86 care homes between 13 January 2014 and 12 November 2015 about residents with dementia with respect to agitation (Cohen-Mansfield Agitation Inventory (CMAI)), quality of life (DEMQOL-proxy) and dementia severity (Clinical Dementia Rating). We also interviewed residents and their relatives. We used random effects models adjusted for resident age, gender, dementia severity and care home type with CMAI as a continuous score.
resultsOut of 3053 (86.2%) residents who had dementia, 1489 (52.7%) eligible residents participated. Fifteen per cent of residents with very mild dementia had clinically significant agitation compared with 33% with mild (odds ratios (ORs)=4.49 95% confidence interval (CI)=2.30) and 45% with moderate or severe dementia (OR=6.95 95% CI=3.63, 13.31 and OR=6.23 95% CI=3.25, 11.94, respectively). More agitation was associated with lower quality of life (regression coefficient (rc)=-0.53; 95% CI=-0.61, -0.46) but not with staffing or resident ratio (rc=0.03; 95% CI=-0.04, 0.11), level of residents' engagement in home activities (rc=3.21; 95% CI=-0.82, 7.21) or family visit numbers (rc=-0.03; 95% CI=-0.15, 0.08). It was correlated with antipsychotic use (rc=6.45; 95% CI=3.98, 8.91).
conclusionsCare home residents with dementia and agitation have lower quality of life. More staffing time and activities as currently provided are not associated with lower agitation levels. New approaches to develop staff skills in understanding and responding to the underlying reasons for individual resident's agitation require development and testing. DECLARATION OF INTEREST: None. COPYRIGHT AND USAGE: © The Royal College of Psychiatrists 2017. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) license.
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