Gut dysbiosis in mice genetically selected for low antibody production.

Ana Carolina da Silva Santos, José Ricardo Jensen, Silvio Luis de Oliveira, Josias Rodrigues

Abstract read

In one paragraph

Article in Gut pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Ana Carolina da Silva SantosDepartment of Microbiology and Immunology, Institute of Biosciences of the State University of São Paulo (UNESP), Campus de Rubião Junior, Botucatu, SP 18618-961 Brazil.

José Ricardo JensenLaboratory of Immunogenetics, Butantan Institute, Av. Dr. Vital Brazil 1500, São Paulo, SP 05503-900 Brazil.

Silvio Luis de OliveiraDepartment of Microbiology and Immunology, Institute of Biosciences of the State University of São Paulo (UNESP), Campus de Rubião Junior, Botucatu, SP 18618-961 Brazil.

Josias RodriguesDepartment of Microbiology and Immunology, Institute of Biosciences of the State University of São Paulo (UNESP), Campus de Rubião Junior, Botucatu, SP 18618-961 Brazil.ORCID 0000-0001-8480-672X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDysbiosis is linked to the cause of several human diseases, many of which having an immunity related component. This work investigated whether mice genetically selected for low or high antibody production display differences in intestinal bacterial communities, and consisted in the comparison of fecal 16SV6-V8 rDNA PCR amplicons resolved by temperature gradient gel electrophoresis (TGGE) of five each of low (LIII) and high (HIII) antibody producing mice. 16SV6 rDNA amplicons of 2 mice from each line were sequenced.

resultsLIII mice were grouped in a single TGGE cluster, displayed a low α-diversity, and were distinguished by low Firmicutes/Bacteroidetes ratio.

conclusionThe results suggest that genetically driven low antibody production in mice is associated with gut dysbiosis.

Indexed as

AntibodyBacteroidetesFirmicutesMicrobiomePrevotellaceaeRuminococcaceae

Identifiers

PMID28794801

DOI10.1186/s13099-017-0193-x

PMCPMC5547450

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