ArticleGut pathogens2017
Genome characterization of a novel binary toxin-positive strain of
Article in Gut pathogens, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Diversity of binary toxin positive Clostridioides difficile in Korea.Scientific reports · 2023Article
- Influence of Binary Toxin Gene Detection and Decreased Susceptibility to Antibiotics among Clostridioides difficile Strains on Disease Severity: a Single-Center Study.Antimicrobial agents and chemotherapy · 2022Article
- An Update onToxins · 2022Review
- Genetic Mechanisms of Vancomycin Resistance inAntibiotics (Basel, Switzerland) · 2022Review
- Characterization of Clostridioides difficile DSM 101085 with A-B-CDT+ Phenotype from a Late Recurrent Colonization.Genome biology and evolution · 2020Article
- Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea.Emerging microbes & infections · 2018Article
- Diagnosis of Clostridium difficile infection using an UPLC-MS based metabolomics method.Metabolomics : Official journal of the Metabolomic Society · 2018Article
- A Novel Bacteriophage Lysin-Human Defensin Fusion Protein Is Effective in Treatment ofFrontiers in microbiology · 2018Article
- Genomic Comparisons Reveal Microevolutionary Differences inFrontiers in microbiology · 2017Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background
resultsThe project finally generated an estimated genome size of approximately 4.07 Mbp for strain LC693. Genome size of the three ST201 strains ranged from 4.07 to 4.16 Mb, with an average GC content between 28.5 and 28.9%. Phylogenetic analysis demonstrated that the ST201 strains belonged to clade 3. The ST201 genomes contained more than 40 antibiotic resistance genes and 15 of them were predicted to be associated with vancomycin-resistance. The ST201 strains contained a larger PaLoc with a Tn6218 element inserted than the 027/ST1 and 078/ST11 strains, and encoded a truncated TcdC. In addition, the ST201 strains contained intact binary toxin coding and regulation genes which are highly homologous to the 027/ST1 strain. Genome comparison of the ST201 strains with the epidemic 027 and 078 strain identified 641 genes specific for
conclusionsIn this study, the genomic characterization of three binary toxin-positive
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