Evidence map›Paper›PMID 28794626›Full record

ArticleInternational journal of nanomedicine2017

Folic acid-functionalized polyethylenimine superparamagnetic iron oxide nanoparticles as theranostic agents for magnetic resonance imaging and PD-L1 siRNA delivery for gastric cancer.

Xin Luo, Xia Peng, Jingying Hou, Shuyun Wu, Jun Shen, Lingyun Wang

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
8.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 104 citations in OpenAlex.

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  14. New Advances in Nano-Drug Delivery Systems:Frontiers in oncology · 2022
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  16. Nanoparticle-MediatedACS nano · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Xin LuoDepartment of Gastroenterology.
Xia PengDepartment of Gastroenterology.
Jingying HouDepartment of Emergency Medicine, Sun Yat-sen Memorial Hospital.
Shuyun WuDepartment of Thoracic Surgery, Sun Yat-sen University Cancer Center.
Jun ShenDepartment of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Lingyun WangDepartment of Gastroenterology.
Sun Yat-sen University · CNUniversity Gastroenterology · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Programmed death ligand-1 (PD-L1), which is highly expressed in gastric cancers, interacts with programmed death-1 (PD-1) on T cells and is involved in T-cell immune resistance. To increase the therapeutic safety and accuracy of PD-1/PD-L1 blockade, RNA interference through targeted gene delivery was performed in our study. We developed folic acid (FA)- and disulfide (SS)-polyethylene glycol (PEG)-conjugated polyethylenimine (PEI) complexed with superparamagnetic iron oxide Fe

Indexed as

B7-H1 AntigenCell SurvivalCoculture TechniquesContrast MediaFerric CompoundsFolic AcidGene Transfer TechniquesHumansMagnetic Resonance ImagingMagnetite NanoparticlesPolyethylene GlycolsPolyethyleneimineRNA, Small InterferingStomach NeoplasmsSuccinimidesTheranostic NanomedicineB7-H1 AntigenCD274 protein, humanContrast MediaFerric Compoundsferric oxideFolic AcidMagnetite Nanoparticlespolyethylene glycol bis(succinimidyl succinate)Polyethylene GlycolsPolyethyleneimineRNA, Small InterferingSuccinimidescellular internalizationmagnetic resonance imagingPEIRNA interferencetheranostics

Identifiers

PMID28794626
PMCPMC5536232
OpenAlexW2739226242

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.