Evidence map›Paper›PMID 28794498›Full record

ArticleScientific reports2017

Analysis of inflammatory cytokine and TLR expression levels in Type 2 Diabetes with complications.

Saket Gupta, Ashwini Maratha, Jakub Siednienko, Anandan Natarajan, Thusitha Gajanayake, Shu Hoashi, Sinéad Miggin

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 65 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 2 pooled it
7.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 121 citations in OpenAlex.

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  15. Novel Insights into Sporotrichosis and Diabetes.Journal of fungi (Basel, Switzerland) · 2024
    Review
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  17. Effect of pegagan (Narra J · 2024
    Article
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  19. Observational
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Saket GuptaMidlands Regional Hospital, Mullingar, Co. Westmeath, Ireland.
Ashwini MarathaImmune Signalling laboratory, Institute of Immunology, Department of Biology, Maynooth University, Maynooth, Ireland.
Jakub SiednienkoImmune Signalling laboratory, Institute of Immunology, Department of Biology, Maynooth University, Maynooth, Ireland.
Anandan NatarajanMidlands Regional Hospital, Mullingar, Co. Westmeath, Ireland.
Thusitha GajanayakeImmune Signalling laboratory, Institute of Immunology, Department of Biology, Maynooth University, Maynooth, Ireland.
Shu HoashiMidlands Regional Hospital, Mullingar, Co. Westmeath, Ireland.
Sinéad MigginImmune Signalling laboratory, Institute of Immunology, Department of Biology, Maynooth University, Maynooth, Ireland. sinead.miggin@nuim.ie.ORCID 0000-0002-3421-3552
National University of Ireland, Maynooth · IEMidland Regional Hospital Mullingar · IEUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The pathogenesis and complications of type 2 diabetes (T2DM) are closely linked with defective glucose metabolism, obesity, cardiovascular disease and an inability to mount an effective immune response to certain pathogenic organisms. Perturbations in key innate immune receptors known as Toll-like receptors (TLRs) and inflammatory mediators such as IL-6, TNFα and IL-1β have been linked with T2DM. Herein, we sought to establish whether patients with T2DM and underlying complications exhibit perturbations in cytokine and TLR expression. Serum cytokine and mRNA levels of cytokines/TLRs in monocytes (M) and neutrophils (N) were measured in a cohort of 112 diabetic patients: good glycaemic control without complications (GC), good glycaemic control with complications (GCC), poor glycaemic control without complications (PC) and poor glycaemic control with complications (PCC) and compared them with 34 non-diabetic volunteers (NGT). Serum cytokine levels were normal in all study participants. In the GC group, cytokine and TLR gene expression were enhanced compared to NGT. In contrast, suppressed cytokine and TLR gene expression were evident in PC, GCC & PCC groups when compared to the GC. In conclusion, whereas serum pro-inflammatory cytokine levels are unaltered in T2DM patients, differences in inflammatory gene profiles exist among the T2DM patient groups.

Indexed as

Gene Expression ProfilingAgedCytokinesDiabetes ComplicationsDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedMonocytesNeutrophilsRNA, MessengerToll-Like ReceptorsCytokinesRNA, MessengerToll-Like Receptors

Identifiers

PMID28794498
PMCPMC5550417
OpenAlexW2742941924

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.