ArticleNature communications2017
Serial processing of kinematic signals by cerebellar circuitry during voluntary whisking.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- Effects of Short-Term Synaptic Plasticity in Feedforward Inhibitory Circuits on Cerebellar Responses to Repetitive Sensory Input.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cerebellar circuit computations for predictive motor control.Nature reviews. Neuroscience · 2025Review
- High-speed voltage imaging of action potentials in molecular layer interneurons reveals sensory-driven synchrony that augments movement.Cell reports · 2025Article
- Article
- GlyT2-Positive Interneurons Regulate Timing and Variability of Information Transfer in a Cerebellar-Behavioral Loop.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Comparing the Representation of a Simple Visual Stimulus across the Cerebellar Network.eNeuro · 2024Article
- Article
- Local synaptic inhibition mediates cerebellar granule cell pattern separation and enables learned sensorimotor associations.Nature neuroscience · 2024Article
- Expression of a Form of Cerebellar Motor Memory Requires Learned Alterations to the Activity of Inhibitory Molecular Layer Interneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Synaptic basis of a sub-second representation of time in a neural circuit model.Nature communications · 2022Article
- Deconstruction of Vermal Cerebellum in Ramp Locomotion in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Brain-Inspired Spiking Neural Network Controller for a Neurorobotic Whisker System.Frontiers in neurorobotics · 2022Article
- Cerebellum as a kernel machine: A novel perspective on expansion recoding in granule cell layer.Frontiers in computational neuroscience · 2022Article
- Interactions among diameter, myelination, and the Na/K pump affect axonal resilience to high-frequency spiking.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Cerebellar granule cell axons support high-dimensional representations.Nature neuroscience · 2021Article
- Accounting for uncertainty: inhibition for neural inference in the cerebellum.Proceedings. Biological sciences · 2021Review
- The Cellular Electrophysiological Properties Underlying Multiplexed Coding in Purkinje Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Review
- Simulation of a Human-Scale Cerebellar Network Model on the K Computer.Frontiers in neuroinformatics · 2020Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Purkinje cells (PCs) in Crus 1 represent whisker movement via linear changes in firing rate, but the circuit mechanisms underlying this coding scheme are unknown. Here we examine the role of upstream inputs to PCs-excitatory granule cells (GCs) and inhibitory molecular layer interneurons-in processing of whisking signals. Patch clamp recordings in GCs reveal that movement is accompanied by changes in mossy fibre input rate that drive membrane potential depolarisation and high-frequency bursting activity at preferred whisker angles. Although individual GCs are narrowly tuned, GC populations provide linear excitatory drive across a wide range of movement. Molecular layer interneurons exhibit bidirectional firing rate changes during whisking, similar to PCs. Together, GC populations provide downstream PCs with linear representations of volitional movement, while inhibitory networks invert these signals. The exquisite sensitivity of neurons at each processing stage enables faithful propagation of kinematic representations through the cerebellum.Cerebellar Purkinje cells (PCs) linearly encode whisker position but the precise circuit mechanisms that generate these signals are not well understood. Here the authors use patch clamp recordings to show that selective tuning of granule cell inputs and bidirectional tuning of interneuron inputs are required to generate the kinematic representations in PCs.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.