ArticleNature communications2017
IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
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- ILC3: a case of conflicted identity.Frontiers in immunology · 2023Review
- CircMolecular and cellular biology · 2023Article
- Circular RNA circTmem241 drives group III innate lymphoid cell differentiation via initiation of Elk3 transcription.Nature communications · 2022Article
- Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent mCellular & molecular immunology · 2021Article
- Interleukin-7 Biology and Its Effects on Immune Cells: Mediator of Generation, Differentiation, Survival, and Homeostasis.Frontiers in immunology · 2021Review
- The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations.Frontiers in cellular neuroscience · 2021Article
- An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.Nature communications · 2020Article
- The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells.The EMBO journal · 2020Article
- Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis.The Journal of experimental medicine · 2020Article
- Abnormal Food Timing Promotes Alcohol-Associated Dysbiosis and Colon Carcinogenesis Pathways.Frontiers in oncology · 2020Article
- Yeats4 drives ILC lineage commitment via activation ofThe Journal of experimental medicine · 2019Article
- Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker.Frontiers in immunology · 2019Review
- IL-7 is a Key Driver Cytokine in Spondyloarthritis?Journal of immunology research · 2019Review
- An Essential Role of Innate Lymphoid Cells in the Pathophysiology of Graft-vs.-Host Disease.Frontiers in immunology · 2019Review
- LncRNA SLCO4A1-AS1 facilitates growth and metastasis of colorectal cancer through β-catenin-dependent Wnt pathway.Journal of experimental & clinical cancer research : CR · 2018Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Group 3 innate lymphoid cells (ILC3) promote lymphoid organogenesis and potentiate immune responses against bacterial infection. However, how ILC3 cells are developed and maintained is still unclear. Here, we show that carboxypeptidase CCP2 is highly expressed in common helper-like innate lymphoid progenitors, the progenitor of innate lymphoid cells, and CCP2 deficiency increases ILC3 numbers. Interleukin-7 receptor subunit alpha (IL-7Rα) is identified as a substrate of CCP2 for deglutamylation, and IL-7Rα polyglutamylation is catalyzed by polyglutamylases TTLL4 and TTLL13 in common helper-like innate lymphoid progenitors. IL-7Rα polyglutamylation triggers STAT5 activation to initiate transcription factor Sall3 expression in common helper-like innate lymphoid progenitors, which drives ILC3 cell differentiation. Moreover, Ttll4
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