Evidence map›Paper›PMID 28794437›Full record

ArticleScientific reports2017

Genetic variation at the CD28 locus and its impact on expansion of pro-inflammatory CD28 negative T cells in healthy individuals.

Evaggelia Liaskou, Louisa Jeffery, Dimitrios Chanouzas, Blagoje Soskic, Michael F Seldin, Lorraine Harper, David Sansom, Gideon M Hirschfield

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Evaggelia LiaskouCentre for Liver Research and NIHR Birmingham Liver Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Louisa JefferyInstitute of Metabolism and Systems Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK.
Dimitrios ChanouzasInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
Blagoje SoskicInstitute of Immunity and Transplantation, University College London and Royal Free Hospital, London, NW3 2PF, UK.
Michael F SeldinDepartment of Biochemistry and Molecular Medicine, University of California at Davis, Davis, CA, 95616, USA.
Lorraine HarperInstitute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.
David SansomInstitute of Immunity and Transplantation, University College London and Royal Free Hospital, London, NW3 2PF, UK.
Gideon M HirschfieldCentre for Liver Research and NIHR Birmingham Liver Biomedical Research Centre, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. g.hirschfield@bham.ac.uk.
University of Birmingham · GBThe Royal Free Hospital · GBUniversity College London · GBUniversity of California, Davis · US

Funding

Biotechnology and Biological Sciences Research Council BB/M009203/1
6 · The paper itself

Abstract

The CD28 locus is associated with susceptibility to a variety of autoimmune and immune-mediated inflammatory diseases including primary sclerosing cholangitis (PSC). Previously, we linked the CD28 pathway in PSC disease pathology and found that vitamin D could maintain CD28 expression. Here, we assessed whether the PSC-associated CD28 risk variant A (rs7426056) affects CD28 expression and T cell function in healthy individuals (n = 14 AA, n = 14 AG, n = 14 GG). Homozygotes for the PSC disease risk allele (AA) showed significantly lower CD28 mRNA expression ex-vivo than either GG or AG (p < 0.001) in total peripheral blood mononuclear cells. However, the CD28 risk variant alone was not sufficient to explain CD28 protein loss on CD4

Indexed as

Genetic LociGenetic VariationAdultAllelesAnimalsCD28 AntigensCell LineDisease SusceptibilityFemaleGene ExpressionGene Knockout TechniquesGenotypeHealthy VolunteersHumansInflammationMaleCD28 AntigensRNA, Messenger

Identifiers

PMID28794437
PMCPMC5550460
OpenAlexW2744338684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.