ArticleProceedings of the National Academy of Sciences of the United States of America2017
Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
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- Quorum-sensingbioRxiv : the preprint server for biology · 2024Article
- Genome-wide screen reveals cellular functions that counteract rifampicin lethality inMicrobiology spectrum · 2024Article
- Enhancement of β-Lactam-Mediated Killing of Gram-Negative Bacteria by Lysine Hydrochloride.Microbiology spectrum · 2023Article
- Physicochemical mechanisms of bacterial response in the photodynamic potentiation of antibiotic effects.Scientific reports · 2022Article
- Reactive metabolic byproducts contribute to antibiotic lethality under anaerobic conditions.Molecular cell · 2022Article
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- Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement.Frontiers in cellular and infection microbiology · 2022Review
- Synergistic Quinolone Sensitization by Targeting theAntimicrobial agents and chemotherapy · 2021Article
- Digital Insights Into Nucleotide Metabolism and Antibiotic Treatment Failure.Frontiers in digital health · 2021Article
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- Inhibitors of DNA Glycosylases as Prospective Drugs.International journal of molecular sciences · 2020Review
- Reactive Oxygen Species in Pathogen Clearance: The Killing Mechanisms, the Adaption Response, and the Side Effects.Frontiers in microbiology · 2020Review
- Mutations of the Bacillus subtilis YidC1 (SpoIIIJ) insertase alleviate stress associated with σM-dependent membrane protein overproduction.PLoS genetics · 2019Article
- Genetic Analysis of Protein Translocation.The protein journal · 2019Review
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Downstream metabolic events can contribute to the lethality of drugs or agents that interact with a primary cellular target. In bacteria, the production of reactive oxygen species (ROS) has been associated with the lethal effects of a variety of stresses including bactericidal antibiotics, but the relative contribution of this oxidative component to cell death depends on a variety of factors. Experimental evidence has suggested that unresolvable DNA problems caused by incorporation of oxidized nucleotides into nascent DNA followed by incomplete base excision repair contribute to the ROS-dependent component of antibiotic lethality. Expression of the chimeric periplasmic-cytoplasmic MalE-LacZ
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