ArticleProceedings. Biological sciences2017
Revised time scales of RNA virus evolution based on spatial information.
Article in Proceedings. Biological sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Host hybridization enabled the emergence of a reassorted hantavirus lineage.PLoS pathogens · 2026Article
- Reconciling fast Hepatitis B evolutionary rates with ancient co-divergence.bioRxiv : the preprint server for biology · 2026Article
- Co-Circulation of Divergent Strains Supports Vector-Mediated Transmission of Rodent Hepacivirus J (Viruses · 2026Article
- Genome-wide support for incipient Tula hantavirus species within a single rodent host lineage.Virus evolution · 2024Article
- Evolutionary Formation and Distribution of Puumala Virus Genome Variants, Russia.Emerging infectious diseases · 2023Article
- Hantavirus Brno loanvirus is highly specific to the common noctule bat (Nyctalus noctula) and widespread in Central Europe.Virus genes · 2023Article
- Continuous presence of genetically diverse rustrela virus lineages in yellow-necked field mouse reservoir populations in northeastern Germany.Virus evolution · 2023Article
- Article
- Host genetic factors associated with the range limit of a European hantavirus.Molecular ecology · 2022Article
- Phylogeographic analysis of Tula hantavirus highlights a single introduction to central Europe.Virus evolution · 2022Article
- Article
- Spatial and Temporal Dynamics and Molecular Evolution ofViruses · 2021Article
- Genetic Diversity ofViruses · 2021Article
- Detection and Genetic Characterization of Puumala Orthohantavirus S-Segment in Areas of France Non-Endemic for Nephropathia Epidemica.Pathogens (Basel, Switzerland) · 2020Article
- Assessing Genome-Wide Diversity in European Hantaviruses through Sequence Capture from Natural Host Samples.Viruses · 2020Article
- Spatial and Temporal Evolutionary Patterns in Puumala Orthohantavirus (PUUV) S Segment.Pathogens (Basel, Switzerland) · 2020Article
- Genetic Characterization and Molecular Evolution of Urban Seoul Virus in Southern China.Viruses · 2019Article
- Field vole-associated Traemmersee hantavirus from Germany represents a novel hantavirus species.Virus genes · 2019Article
- Phylogeography of Puumala orthohantavirus in Europe.Viruses · 2019Article
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Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The time scales of pathogen evolution are of major concern in the context of public and veterinary health, epidemiology and evolutionary biology. Dating the emergence of a pathogen often relies on estimates of evolutionary rates derived from nucleotide sequence data. For many viruses, this has yielded estimates of evolutionary origins only a few hundred years in the past. Here we demonstrate through the incorporation of geographical information from virus sampling that evolutionary age estimates of two European hantaviruses are severely underestimated because of pervasive mutational saturation of nucleotide sequences. We detected very strong relationships between spatial distance and genetic divergence for both Puumala and Tula hantavirus-irrespective of whether nucleotide or derived amino acid sequences were analysed. Extrapolations from these relationships dated the emergence of these viruses most conservatively to at least 3700 and 2500 years ago, respectively. Our minimum estimates for the age of these hantaviruses are ten to a hundred times older than results from current non-spatial methods, and in much better accordance with the biogeography of these viruses and their respective hosts. Spatial information can thus provide valuable insights on the deeper time scales of pathogen evolution and improve our understanding of disease emergence.
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