Evidence map›Paper›PMID 28794206›Full record

Trial reportThe Journal of nutrition2017

Lipid-Based Nutrient Supplements During Pregnancy and Lactation Did Not Affect Human Milk Oligosaccharides and Bioactive Proteins in a Randomized Trial.

Josh M Jorgensen, Charles Arnold, Per Ashorn, Ulla Ashorn, David Chaima, Yin Bun Cheung, Jasmine Cc Davis, Yue-Mei Fan, Elisha Goonatilleke, Emma Kortekangas and 6 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01239693 (A Research Plan for a Randomised, Single-blind, Parallel Group Controlled Trial in Rural Malawi, Testing the Health Effects of Supplementing Maternal Diet During Pregnancy and Lactation and Infant Diet From 6 to 18 Months of Age With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements), which is not on this map. Cited by 19 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01239693 phase3active not recruitingnot on this map

A Research Plan for a Randomised, Single-blind, Parallel Group Controlled Trial in Rural Malawi, Testing the Health Effects of Supplementing Maternal Diet During Pregnancy and Lactation and Infant Diet From 6 to 18 Months of Age With High-energy, Micronutrient Fortified Lipid-based Nutrient Supplements (LNS)

TypeinterventionalSponsorTampere UniversityRan2011 to 2027Enrolled1,391ConditionsInfant Malnutrition, Malnutrition in PregnancyArmsIFA, MMN, LNS
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 4 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Multiple-micronutrient supplementation for women during pregnancy.The Cochrane database of systematic reviews · 2019
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Nutrients · 2021
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 4 countries.

Josh M JorgensenDepartment of Nutrition, University of California, Davis, Davis, CA.
Charles ArnoldDepartment of Nutrition, University of California, Davis, Davis, CA.
Per AshornFaculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Ulla AshornDepartment of Biochemistry and Molecular Medicine, University of California, Davis, Davis, CA.
David ChaimaDepartment of Community Health, University of Malawi College of Medicine, Blantyre, Malawi.
Yin Bun CheungCentre for Quantitative Medicine, Duke-National University of Singapore Graduate Medical School, Singapore, Singapore.
Jasmine Cc DavisDepartment of Chemistry, University of California, Davis, Davis, CA.
Yue-Mei FanFaculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Elisha GoonatillekeDepartment of Chemistry, University of California, Davis, Davis, CA.
Emma KortekangasFaculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Chiza KumwendaDepartment of Community Health, University of Malawi College of Medicine, Blantyre, Malawi.
Carlito B LebrillaDepartment of Chemistry, University of California, Davis, Davis, CA.
Kenneth MaletaDepartment of Community Health, University of Malawi College of Medicine, Blantyre, Malawi.
Sarah M TottenDepartment of Chemistry, University of California, Davis, Davis, CA.
Lauren D WuDepartment of Chemistry, University of California, Davis, Davis, CA.
Kathryn G DeweyDepartment of Nutrition, University of California, Davis, Davis, CA.
University of California, Davis · USTampere University · FIUniversity of Malawi · MWNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman milk oligosaccharides (HMOs) and bioactive proteins are beneficial to infant health. Recent evidence suggests that maternal nutrition may affect the amount of HMOs and proteins in breast milk; however, the effect of nutrient supplementation on HMOs and bioactive proteins has not yet been well studied.

objectiveWe aimed to determine whether lipid-based nutrient supplements (LNSs) affect milk bioactive protein and HMO concentrations at 6 mo postpartum in women in rural Malawi. These are secondary outcomes of a previously published randomized controlled trial.

methodsWomen were randomly assigned to consume either an iron and folic acid capsule (IFA) daily from ≤20 wk gestation until delivery, followed by placebo daily from delivery to 6 mo postpartum, or a multiple micronutrient (MMN) capsule or LNS daily from ≤20 wk gestation to 6 mo postpartum. Breast milk concentrations of total HMOs, sialylated HMOs, fucosylated HMOs, lactoferrin, lactalbumin, lysozymes, antitrypsin, immunoglobulin A, and osteopontin were analyzed at 6 mo postpartum (n = 647). Between-group differences in concentrations and in proportions of women classified as having low concentrations were tested.

resultsHMO and bioactive protein concentrations did not differ between groups (P > 0.10 for all comparisons). At 6 mo postpartum, the proportions of women with low HMOs or bioactive proteins were not different between groups except for osteopontin. A lower proportion of women in the IFA group had low osteopontin compared with the LNS group after adjusting for covariates (OR: 0.5; 95% CI: 0.3, 0.9; P = 0.016).

conclusionThe study findings do not support the hypothesis that supplementation with an LNS or MMN capsule during pregnancy and postpartum would increase HMO or bioactive milk proteins at 6 mo postpartum among Malawian women. This trial was registered at clinicaltrials.gov as NCT01239693.

Indexed as

Dietary SupplementsAdultFemaleHumansLactationLipidsMicronutrientsMilk, HumanMilk ProteinsOligosaccharidesPregnancyLipidsMicronutrientsMilk ProteinsOligosaccharidesbioactive breast milk proteinshuman milk oligosaccharideslactationlipid-based nutrient supplementsmultiple micronutrient supplementspostpartum

Identifiers

PMID28794206
PMCPMC5610548
OpenAlexW2744510898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.