Evidence map›Paper›PMID 28794202›Full record

ArticleEMBO reports2017

CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.

Yawei Li, Fuxin Zheng, Xingyuan Xiao, Fei Xie, Dan Tao, Chao Huang, Dong Liu, Miao Wang, Liang Wang, Fuqing Zeng and 1 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EMBO reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 340 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
340citing papers in PubMed, 2 pooled it
36.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

340 citing papers in PubMed, 2 syntheses or guidelines pooled it, 585 citations in OpenAlex.

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  9. Circular RNAs: from transcriptional noise to engineered therapeutics.Frontiers in epigenetics and epigenomics · 2026
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280 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Yawei LiDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fuxin ZhengDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xingyuan XiaoDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fei XieDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dan TaoDepartment of Oncology, The Fifth Hospital of Wuhan, Wuhan, China.
Chao HuangDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Dong LiuDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Miao WangDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liang WangDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fuqing ZengDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China zengfuqingpro@163.com jiangguosongdoc@hotmail.com.ORCID 0000-0003-2059-0952
Guosong JiangDepartment of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China zengfuqingpro@163.com jiangguosongdoc@hotmail.com.ORCID 0000-0002-2766-5016
Wuhan Union Hospital · CNWuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidences suggest that circular RNAs (circRNAs) exert crucial functions in regulating gene expression. In this study, we perform RNA-seq and identify 6,154 distinct circRNAs from human bladder cancer and normal bladder tissues. We find that hundreds of circRNAs are significantly dysregulated in human bladder cancer tissues. We further show that circHIPK3, also named bladder cancer-related circular RNA-2 (BCRC-2), is significantly down-regulated in bladder cancer tissues and cell lines, and negatively correlates with bladder cancer grade, invasion as well as lymph node metastasis, respectively. Over-expression of circHIPK3 effectively inhibits migration, invasion, and angiogenesis of bladder cancer cells

Indexed as

Gene Expression Regulation, NeoplasticCell Line, TumorCell ProliferationDown-RegulationGlucuronidaseHeparanaseHumansIntracellular Signaling Peptides and ProteinsMicroRNAsNeovascularization, PathologicProtein Serine-Threonine KinasesRNARNA, CircularRNA, NeoplasmSequence Analysis, RNAUrinary Bladder NeoplasmsGlucuronidaseHeparanaseHIPK3 protein, humanIntracellular Signaling Peptides and ProteinsMicroRNAsMIRN-558 microRNA, humanProtein Serine-Threonine KinasesRNARNA, CircularRNA, Neoplasmbladder cancercircHIPK3circular RNAheparanasemiR‐558

Identifiers

PMID28794202
PMCPMC5579470
OpenAlexW2742872127

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.