ReviewEuropean respiratory review : an official journal of the European Respiratory Society2017
Nasal high flow therapy: a novel treatment rather than a more expensive oxygen device.
Review in European respiratory review : an official journal of the European Respiratory Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nasal High Flow Versus Non-Invasive Ventilation in Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease
Open Randomized Controlled Clinical Trial Comparing Oxygen Therapy by High Flow Nasal Cannulae and by Venturi Mask in the Treatment of Acute Respiratory Failure Due to Severe Pneumonia (Hi Flow Oxygen vs Venturi Mask In Pneumonia)
Asymmetric (DUET) Versus Conventional Nasal High Flow Interface for Management of Hypercapnic Patients With Mild to Moderate Acute Exacerbation of COPD: A Randomized, Crossover Clinical Trial
Uso de Lentillas de Alto Flujo en Procedimientos de sustitución de válvula aórtica transcatéter. Impacto en Las Complicaciones Respiratorias y Biomarcado- Res y Resultados clínicos. TAVR-Highflow
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 81 citations in OpenAlex.
- High-Flow Nasal Oxygen Versus Conventional Oxygen Therapy and Non-Invasive Ventilation for Acute Respiratory Failure in the Emergency Department: A Systematic Review and Meta-Analysis.Emergency medicine Australasia : EMA · 2026Pooled it
- Comparison of clinical outcomes between high-flow nasal cannula and non-invasive ventilation in acute exacerbation of COPD: a meta-analysis of randomized controlled trials.BMC pulmonary medicine · 2025Pooled it
- Effect of noninvasive respiratory support on interstitial lung disease with acute respiratory failure: A systematic review and meta-analysis.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023Pooled it
- High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial.Critical care (London, England) · 2022Trial
- [High-flow nasal cannula oxygen therapy can reduce occurrence of hypoxia in elderly patients during anesthesia recovery].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Trial
- Automatic versus manual oxygen titration using a novel nasal high-flow device in medical inpatients with an acute illness: a randomised controlled trial.BMJ open respiratory research · 2021Trial
- Intravenous Sedation of a Patient With Morbid Obesity and Severe Sleep Apnea Syndrome for Dental Treatment: A Case Report.Anesthesia progress · 2026Article
- High-Flow Nasal Oxygenation During Sedation for Transcatheter Aortic Valve Replacement: The HIGH-OXY-TAVR Randomised-Controlled Trial.Journal of clinical medicine · 2025Article
- Current Practice and Barriers to Using High-Flow Nasal Cannula Among ARDS Patients in Saudi Arabia: A Cross-Sectional Study of Physicians.Health science reports · 2025Article
- THE EFFECTIVENESS OF HIGH FLOW OXYGEN THERAPY AND NONINVASIVE MECHANICAL VENTILATION TREATMENT IN ACUTE RESPIRATORY FAILURE DUE TO CHRONIC OBSTRUCTIVE PULMONARY DISEASE - A RANDOMIZED STUDY.Acta clinica Croatica · 2025Article
- High-flow nasal cannula oxygen therapy: physiological basis and clinical applications in anesthesia.Frontiers in medicine · 2025Review
- Clinical Practice of High-Flow Nasal Cannula Therapy in ARDS Patients: A Cross-Sectional Survey of Respiratory Therapists.Journal of multidisciplinary healthcare · 2024Article
- High-Flow Nasal Cannula Therapy as an Adjuvant Therapy for Respiratory Support during Endoscopic Techniques: A Narrative Review.Journal of clinical medicine · 2023Review
- Article
- Article
- Article
- High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy in intensive care unit patients after extubation.American journal of translational research · 2023Article
- Respiratory support of adults in the emergency department: A protocol for a prospective, observational, multicenter point prevalence study.Health science reports · 2023Article
- The use of High-Flow Nasal Oxygen Therapy in 4 dogs undergoing bronchoscopy.Frontiers in veterinary science · 2023Article
- IPF Respiratory Symptoms Management - Current Evidence.Frontiers in medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nasal high flow is a promising novel oxygen delivery device, whose mechanisms of action offer some beneficial effects over conventional oxygen systems. The administration of a high flow of heated and humidified gas mixture promotes higher and more stable inspiratory oxygen fraction values, decreases anatomical dead space and generates a positive airway pressure that can reduce the work of breathing and enhance patient comfort and tolerance. Nasal high flow has been used as a prophylactic tool or as a treatment device mostly in patients with acute hypoxaemic respiratory failure, with the majority of studies showing positive results. Recently, its clinical indications have been expanded to post-extubated patients in intensive care or following surgery, for pre- and peri-oxygenation during intubation, during bronchoscopy, in immunocompromised patients and in patients with "do not intubate" status. In the present review, we differentiate studies that suggest an advantage (benefit) from other studies that do not suggest an advantage (no benefit) compared to conventional oxygen devices or noninvasive ventilation, and propose an algorithm in cases of nasal high flow application in patients with acute hypoxaemic respiratory failure of almost any cause.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.