Evidence map›Paper›PMID 28794136›Full record

ArticleHeart (British Cardiac Society)2017

Neutrophil gelatinase-associated lipocalin prior to cardiac surgery predicts acute kidney injury and mortality.

Heerajnarain Bulluck, Raju Maiti, Bibhas Chakraborty, Luciano Candilio, Tim Clayton, Richard Evans, David P Jenkins, Shyam Kolvekar, Gudrun Kunst, Christopher Laing and 4 more

Abstract read
In one paragraph

Article in Heart (British Cardiac Society), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Acute Kidney Injury Biomarker Responses to Short-Term Heat Acclimation.International journal of environmental research and public health · 2020
    Article
  7. Article
  8. Article
  9. Article
  10. Modulating NADNature medicine · 2018
    Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Heerajnarain BulluckNational Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.
Raju MaitiCentre for Quantitative Medicine Duke-NUS Medical School Academia, Singapore, Singapore.
Bibhas ChakrabortyCentre for Quantitative Medicine Duke-NUS Medical School Academia, Singapore, Singapore.
Luciano CandilioThe Hatter Cardiovascular Institute, University College, London, UK.
Tim ClaytonDepartment of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK.
Richard EvansDepartment of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK.
David P JenkinsPapworth Hospital, Cambridge, UK.
Shyam KolvekarBarts Heart Centre, St Bartholomew's Hospital, London, UK.
Gudrun KunstAnaesthetics, Intensive Care Medicine and Perioperative Pain Medicine, King's College Hospital and King's College London, London, UK.
Christopher LaingThe Royal Free Hospital, London, UK.
Jennifer NicholasDepartment of Medical Statistics, London School of Hygiene & Tropical Medicine, London, UK.
John PepperNational Institute of Health Research Cardiovascular Biomedical Research Unit at Royal Brompton & Harefield National Health Service Trust, London, UK.
Derek M YellonThe Hatter Cardiovascular Institute, University College, London, UK.
Derek J HausenloyNational Heart Research Institute Singapore, National Heart Centre, Singapore, Singapore.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to investigate whether preoperative serum neutrophil gelatinase-associated lipocalin (sNGAL

methodsThis study was a post hoc analysis of the Effect of Remote Ischemic Preconditioning on Clinical Outcomes in Patient Undergoing Coronary Artery Bypass Graft Surgery trial involving adult patients undergoing coronary artery bypass graft. Postoperative AKI within 72 hours was defined using the International Kidney Disease: Improving Global Outcomes classification.

results1371 out of 1612 patients had data on sNGAL

conclusionIn a cohort of high-risk adult patients undergoing cardiac surgery, there was an increase in postoperative AKI and 1-year mortality from the first to the third tertile of preoperative serum NGAL. Those in the last tertile (>220 ng/L) had an estimated twofold increase risk of cardiovascular and all-cause mortality at 1 year. CLINICAL

trial registrationNCT101247545; Post-results.

Indexed as

coronary artery diseasecoronary artery disease surgery

Identifiers

PMID28794136
PMCPMC5861395

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.