ArticleCirculation. Arrhythmia and electrophysiology2017
Mechanically Induced Ectopy via Stretch-Activated Cation-Nonselective Channels Is Caused by Local Tissue Deformation and Results in Ventricular Fibrillation if Triggered on the Repolarization Wave Edge (Commotio Cordis).
Article in Circulation. Arrhythmia and electrophysiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The trial behind it
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Article
- Mechano-electrical feedback in transgenic rabbit models of long QT syndrome Type 2 and short QT syndrome Type 1.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Stretch-Induced Increase in CaJournal of the American Heart Association · 2025Article
- Commotio Cordis in Sudden Cardiac Death in the Young: A State-of-the-Art Review.Reviews in cardiovascular medicine · 2025Review
- Disturbed Repolarization-Relaxation Coupling During Acute Myocardial Ischemia Permits Systolic Mechano-Arrhythmogenesis.Circulation research · 2025Article
- Lower diastolic tension may be indicative of higher proarrhythmic propensity in failing human cardiomyocytes.Scientific reports · 2024Article
- Stretch of the papillary insertion triggers reentrant arrhythmia: anFrontiers in physiology · 2024Article
- Advancing Commotio cordis Safety Standards Using the Total Human Models for Safety (THUMS).Annals of biomedical engineering · 2023Article
- Moderator Band and Ventricular Tachycardia: Structural or Functional Substrate?Journal of cardiovascular development and disease · 2023Review
- Endocardial role in arrhythmias induced by acute ventricular stretch and the involvement of Purkinje fibres, in isolated rat hearts.Current research in physiology · 2023Article
- Attenuation of stretch-induced arrhythmias following chemical ablation of Purkinje fibres, in isolated rabbit hearts.Frontiers in physiology · 2023Article
- Guidelines for assessment of cardiac electrophysiology and arrhythmias in small animals.American journal of physiology. Heart and circulatory physiology · 2022Review
- Active force generation contributes to the complexity of spontaneous activity and to the response to stretch of murine cardiomyocyte cultures.The Journal of physiology · 2022Article
- Catheter ablation of short-coupled variant of torsade de pointes.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Article
- An autonomously swimming biohybrid fish designed with human cardiac biophysics.Science (New York, N.Y.) · 2022Article
- Mechano-electric and mechano-chemo-transduction in cardiomyocytes.The Journal of physiology · 2020Review
- Optical mapping of electromechanics in intact organs.Experimental biology and medicine (Maywood, N.J.) · 2020Article
- The Lectin LecA Sensitizes the Human Stretch-Activated Channel TREK-1 but Not Piezo1 and Binds Selectively to Cardiac Non-myocytes.Frontiers in physiology · 2020Article
- Bioenergetic Feedback between Heart Cell Contractile Machinery and Mitochondrial 3D Deformations.Biophysical journal · 2018Article
- Effects of gadolinium on cardiac mechanosensitivity in whole isolated swine hearts.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundExternal chest impacts (commotio cordis) can cause mechanically induced premature ventricular excitation (PVE METHODS AND
resultsSubcontusional mechanical stimuli were applied to isolated rabbit hearts during optical voltage mapping, combined with pharmacological block of ATP-inactivated potassium or stretch-activated cation-nonselective channels. We demonstrate that local mechanical stimulation reliably triggers PVE
conclusionsLocal mechanical tissue deformation determines PVE
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.