Evidence map›Paper›PMID 28794041›Full record

ArticleJournal of virology2017

Interferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon.

Hisashi Akiyama, Nora-Guadalupe Pina Ramirez, Gregory Gibson, Christopher Kline, Simon Watkins, Zandrea Ambrose, Suryaram Gummuluru

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 53 citations in OpenAlex.

  1. Trial
  2. Type I interferon-induced CD169Journal of periodontology · 2026
    Article
  3. Review
  4. CD169Frontiers in cellular and infection microbiology · 2026
    Article
  5. Article
  6. Article
  7. Human CD123Journal of virus eradication · 2025
    Article
  8. Article
  9. Review
  10. CD169iScience · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Breast cancer associated CD169Frontiers in immunology · 2023
    Article
  16. Blood monocyte-derived CD169Nature communications · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Virus-Mimicking Polymer Nanoparticles Targeting CD169ACS applied materials & interfaces · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hisashi AkiyamaDepartment of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA.
Nora-Guadalupe Pina RamirezDepartment of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA.
Gregory GibsonCenter for Biologic Imaging and Department of Cell Biology and Molecular Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Christopher KlineDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Simon WatkinsCenter for Biologic Imaging and Department of Cell Biology and Molecular Physiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Zandrea AmbroseDivision of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Suryaram GummuluruDepartment of Microbiology, Boston University School of Medicine, Boston, Massachusetts, USA rgummulu@bu.edu.ORCID http://orcid.org/0000-0002-8606-8481
University of Pittsburgh · USBoston University · US

Funding

Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
X-Ray Core P50GM082251 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALERO, GUILLERMO ALBERTO · 2007 to 2018
$48.1M
Mechanism of cell-associated HIV-1 transmissionR01AI064099 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GUMMULURU, SURYARAM · 2005 to 2020
$5.9M
Reproductive Hormones and their impact on HIV-1 acquisitionR01HD072693 · NICHD · RHODE ISLAND HOSPITAL · PI CU-UVIN, SUSAN, GUPTA, PHALGUNI · 2012 to 2016
$2.3M
Origin and Evolution of HIV-1 Drug Resistance in the RT-SHIVmne Macaque ModelR01AI080290 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI AMBROSE, ZANDREA · 2010 to 2013
$1.5M
Antiviral Therapy and HIV in the Genital Tract of WomenK24AI066884 · NIAID · MIRIAM HOSPITAL · PI CU-UVIN, SUSAN · 2005 to 2009
$738k
NIAID NIH HHS K24 AI066884NIAID NIH HHS P30 AI042853NIAID NIH HHS R01 AI064099NIAID NIH HHS R01 AI080290NICHD NIH HHS R01 HD072693NIGMS NIH HHS P50 GM082251
6 · The paper itself

Abstract

A hallmark of human immunodeficiency virus type 1 (HIV-1) infection

Indexed as

AnimalsAntiviral AgentsCD4-Positive T-LymphocytesCells, CulturedDendritic CellsHIV-1HIV InfectionsHumansInterferon-alphaMacaca nemestrinaMacrophagesSialic Acid Binding Ig-like Lectin 1Simian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAntiviral AgentsInterferon-alphaSialic Acid Binding Ig-like Lectin 1SIGLEC1 protein, humanCD169HIVtype I IFNvirus entryvirus evasion

Identifiers

PMID28794041
PMCPMC5640826
OpenAlexW2744772724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.