Evidence map›Paper›PMID 28794033›Full record

ArticleJournal of virology2017

Ancient Evolution and Dispersion of Human Papillomavirus 58 Variants.

Zigui Chen, Wendy C S Ho, Siaw Shi Boon, Priscilla T Y Law, Martin C W Chan, Rob DeSalle, Robert D Burk, Paul K S Chan

Abstract read
In one paragraph

Article in Journal of virology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zigui ChenDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-8577-1298
Wendy C S HoDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Siaw Shi BoonDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Priscilla T Y LawDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Martin C W ChanDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.ORCID http://orcid.org/0000-0002-1568-1596
Rob DeSalleSackler Institute of Comparative Genomics, American Museum of Natural History, New York, New York, USA.
Robert D BurkDepartments of Pediatrics, Microbiology and Immunology, Epidemiology and Population Health, and Obstetrics, Gynecology, and Women's Health, Albert Einstein College of Medicine, Bronx, New York, USA.
Paul K S ChanDepartment of Microbiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China paulkschan@cuhk.edu.hk.

Funding

PERSISTENT HUMAN PAPILLOMAVIRUS IN WOMEN AT RISK FOR CERVIX CANCERU01CA078527 · NCI · YESHIVA UNIVERSITY · PI BURK, ROBERT D · 2003 to 2018
$8.6M
NCI NIH HHS U01 CA078527
6 · The paper itself

Abstract

Human papillomavirus 58 (HPV58) is found in 10 to 18% of cervical cancers in East Asia but is rather uncommon elsewhere. The distribution and oncogenic potential of HPV58 variants appear to be heterogeneous, since the E7 T20I/G63S variant is more prevalent in East Asia and confers a 7- to 9-fold-higher risk of cervical precancer and cancer. However, the underlying genomic mechanisms that explain the geographic and carcinogenic diversity of HPV58 variants are still poorly understood. In this study, we used a combination of phylogenetic analyses and bioinformatics to investigate the deep evolutionary history of HPV58 complete genome variants. The initial splitting of HPV58 variants was estimated to occur 478,600 years ago (95% highest posterior density [HPD], 391,000 to 569,600 years ago). This divergence time is well within the era of speciation between

Indexed as

Evolution, MolecularGenetic VariationCapsid ProteinsGenome, ViralHumansPapillomaviridaePapillomavirus InfectionsPhylogenySelection, GeneticCapsid Proteinscervical cancerevolutionHPV58oncogenicitypapillomavirusvirus-host codivergence

Identifiers

PMID28794033
PMCPMC5640864

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.