Evidence map›Paper›PMID 28793871›Full record

Trial reportBMC nephrology2017

Diagnostic accuracy of contrast-enhanced ultrasound for characterization of kidney lesions in patients with and without chronic kidney disease.

Emily Hueywen Chang, Wui Kheong Chong, Sandeep Kumar Kasoji, Julia Rose Fielding, Ersan Altun, Lee B Mullin, Jung In Kim, Jason Peter Fine, Paul Alexander Dayton, Wendy Kimryn Rathmell

Registry-linked trialAbstract readClinical TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC nephrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01751529 (LCCC 1219), which is not on this map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01751529 early_phase1completednot on this map

LCCC 1219: A Prospective Pilot Study Evaluating Renal Lesions Through Contrast-enhanced US in Patients With Renal Cancer and in Those With a Risk Factor for Renal Malignancy

TypeinterventionalSponsorUNC Lineberger Comprehensive Cancer CenterRan2013 to 2015Enrolled48ConditionsKidney CancerArmsContrast-enhanced Ultrasound, Perflutren lipid
3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Isoechoic Renal Tumors: A Case Report and Literature Review.Diagnostics (Basel, Switzerland) · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Emily Hueywen ChangUniversity of North Carolina, 7024 Burnett Womack, CB 7155, Chapel Hill, NC, 27599, USA. emily_chang@med.unc.edu.
Wui Kheong ChongDiagnostic Radiology, Abdominal Imaging Section, The University of Texas MD Anderson Cancer Center, Unit 1473 FCT15.5092, 1400 Pressler Street, Houston, TX, 77030, USA.
Sandeep Kumar KasojiJoint Biomedical Engineering Department, University of North Carolina at Chapel Hill/NCSU, CB 7575, Chapel Hill, NC, 27599, USA.
Julia Rose FieldingPresent address: University of Texas Southwestern at Dallas, 5323 Harry Hines Boulevard, Dallas, TX, 75390-8827, USA.
Ersan AltunDepartment of Radiology, University of North Carolina at Chapel Hill, CB 7510, Chapel Hill, NC, 27599, USA.
Lee B MullinJoint Biomedical Engineering Department, University of North Carolina at Chapel Hill/NCSU, CB 7575, Chapel Hill, NC, 27599, USA.
Jung In KimDepartment of Biostatistics, University of North Carolina, 3101 McGavran-Greenberg Hall, CB #7420, Chapel Hill, NC, 27599-7420, USA.
Jason Peter FineDepartment of Biostatistics, University of North Carolina, 3101 McGavran-Greenberg Hall, CB #7420, Chapel Hill, NC, 27599-7420, USA.
Paul Alexander DaytonJoint Biomedical Engineering Department, University of North Carolina at Chapel Hill/NCSU, CB 7575, Chapel Hill, NC, 27599, USA.
Wendy Kimryn RathmellPresent address: Department of Medicine, Division of Hematology and Oncology, Vanderbilt University, 777 Preston Research Building, Nashville, TN, 37232, USA.

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
Enhancing Translational Science via Prospective InvestigationK24CA172355 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI RATHMELL, WENDY KIMRYN · 2013 to 2017
$870k
NCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1 TR002489NCI NIH HHS K24 CA172355
6 · The paper itself

Abstract

backgroundPatients with chronic kidney disease are at increased risk of cystic kidney disease that requires imaging monitoring in many cases. However, these same patients often have contraindications to contrast-enhanced computed tomography and magnetic resonance imaging. This study evaluates the accuracy of contrast-enhanced ultrasound (CEUS), which is safe for patients with chronic kidney disease, for the characterization of kidney lesions in patients with and without chronic kidney disease.

methodsWe performed CEUS on 44 patients, both with and without chronic kidney disease, with indeterminate or suspicious kidney lesions (both cystic and solid). Two masked radiologists categorized lesions using CEUS images according to contrast-enhanced ultrasound adapted criteria. CEUS designation was compared to histology or follow-up imaging in cases without available tissue in all patients and the subset with chronic kidney disease to determine sensitivity, specificity and overall accuracy.

resultsAcross all patients, CEUS had a sensitivity of 96% (95% CI: 84%, 99%) and specificity of 50% (95% CI: 32%, 68%) for detecting malignancy. Among patients with chronic kidney disease, CEUS sensitivity was 90% (95% CI: 56%, 98%), and specificity was 55% (95% CI: 36%, 73%).

conclusionsCEUS has high sensitivity for identifying malignancy of kidney lesions. However, because specificity is low, modifications to the classification scheme for contrast-enhanced ultrasound could be considered as a way to improve contrast-enhanced ultrasound specificity and thus overall performance. Due to its sensitivity, among patients with chronic kidney disease or other contrast contraindications, CEUS has potential as an imaging test to rule out malignancy.

trial registrationThis trial was registered in clinicaltrials.gov, NCT01751529 .

Indexed as

Contrast MediaAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPilot ProjectsProspective StudiesRenal Insufficiency, ChronicUltrasonographyContrast MediaChronic kidney diseaseContrastContrast-enhanced ultrasoundKidneyKidney lesionUltrasound

Identifiers

PMID28793871
PMCPMC5551034

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.