Evidence map›Paper›PMID 28793839›Full record

ReviewTissue engineering. Part A2017

Barbara D Boyan, Ethan M Lotz, Zvi Schwartz

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Tissue engineering. Part A, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 3 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 3 syntheses or guidelines pooled it, 177 citations in OpenAlex.

  1. Pooled it
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Barbara D Boyan1 Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University , Richmond, Virginia.
Ethan M Lotz1 Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University , Richmond, Virginia.
Zvi Schwartz1 Department of Biomedical Engineering, School of Engineering, Virginia Commonwealth University , Richmond, Virginia.
The University of Texas Health Science Center at San Antonio · USThe Wallace H. Coulter Department of Biomedical Engineering · USVirginia Commonwealth University · US

Funding

Research Training Program Plan on Cell and Tissue Engineering (CTEng)T32GM008433 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 1991 to 2021
$7.1M
NIGMS NIH HHS T32 GM008433
6 · The paper itself

Abstract

Successful dental and orthopedic implant outcomes are determined by the degree of osseointegration. Over the last 60 years, endosseous implants have evolved to stimulate osteogenesis without the need for exogenous biologics such as bone morphogenetic proteins. An understanding of the interaction between cells and the physical characteristics of their environments has led to development of bioactive implants. Implant surfaces that mimic the inherent chemistry, topography, and wettability of native bone have shown to provide cells in the osteoblast lineage with the structural cues to promote tissue regeneration and net new bone formation. Studies show that attachment, proliferation, differentiation, and local factor production are sensitive to these implant surface characteristics. This review focuses on how surface properties, including chemistry, topography, and hydrophilicity, modulate protein adsorption, cell behavior, biological reactions, and signaling pathways in peri-implant bone tissue, allowing the development of true biomimetics that promote osseointegration by providing an environment suitable for osteogenesis.

Indexed as

Dental ImplantsHydrophobic and Hydrophilic InteractionsImplants, ExperimentalOsteogenesisAnimalsBiomimetic MaterialsHumansSurface PropertiesDental Implantsbiomimeticimplantmesenchymal stem cellosteoblastosteoclasttitanium

Identifiers

PMID28793839
PMCPMC5729880
OpenAlexW2767435144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.