ArticleMaterials (Basel, Switzerland)2015
Influence of Different Three-Dimensional Open Porous Titanium Scaffold Designs on Human Osteoblasts Behavior in Static and Dynamic Cell Investigations.
Article in Materials (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The trial behind it
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Who cites it
33 citing papers in PubMed.
- Fabrication and characterization of novel PLA/CH/GelMA/hydroxyapatite electrospun nanofibers for bone tissue regeneration.RSC advances · 2026Article
- Advancing 3D scaffold models for metastatic prostate cancer in bone: Materials, manufacture, and future perspectives.Biomaterials and biosystems · 2025Review
- Evaluating Surface Properties and Cellular Responses to Surface-Treated Different Triple Periodic Minimal Surface L-PBF Ti6Al4V Lattices for Biomedical Devices.International journal of molecular sciences · 2025Article
- Nickel-titanium alloy porous scaffolds based on a dominant cellular structure manufactured by laser powder bed fusion have satisfactory osteogenic efficacy.Materials today. Bio · 2024Article
- In Vitro Proliferation of MG-63 Cells in Additively Manufactured Ti-6Al-4V Biomimetic Lattice Structures with Varying Strut Geometry and Porosity.Materials (Basel, Switzerland) · 2024Article
- Porous metal implants: processing, properties, and challenges.International journal of extreme manufacturing · 2023Review
- Design of Ti64/Ta Hybrid Materials by Powder Metallurgy Mimicking Bone Structure.Materials (Basel, Switzerland) · 2023Article
- Comparison of Osteoconductive Ability of Two Types of Cholesterol-Bearing Pullulan (CHP) Nanogel-Hydrogels Impregnated with BMP-2 and RANKL-Binding Peptide: Bone Histomorphometric Study in a Murine Calvarial Defect Model.International journal of molecular sciences · 2023Article
- Functionalization of 3D-Printed Titanium Scaffolds with Elastin-like Recombinamers to Improve Cell Colonization and Osteoinduction.Pharmaceutics · 2023Article
- Article
- High porosity 3D printed titanium mesh allows better bone regeneration.BMC oral health · 2023Article
- The effect of nodal connectivity and strut density within stochastic titanium scaffolds on osteogenesis.Frontiers in bioengineering and biotechnology · 2023Article
- Research progress and clinical translation of three-dimensional printed porous tantalum in orthopaedics.Biomaterials translational · 2023Review
- Effects of Thermal Stress on the Formation and Cracking Behavior of Nickel-Based Superalloys by Selective Laser Melting Based on a Coupled Thermo-Mechanical Model.Materials (Basel, Switzerland) · 2022Article
- Definition, measurement, and function of pore structure dimensions of bioengineered porous bone tissue materials based on additive manufacturing: A review.Frontiers in bioengineering and biotechnology · 2022Review
- Article
- Structural and Material Determinants Influencing the Behavior of Porous Ti and Its Alloys Made by Additive Manufacturing Techniques for Biomedical Applications.Materials (Basel, Switzerland) · 2021Review
- 3D Printing Technologies in Metallic Implants: A Thematic Review on the Techniques and Procedures.International journal of bioprinting · 2021Review
- Porous Tantalum VS. Titanium Implants: Enhanced Mineralized Matrix Formation after Stem Cells Proliferation and Differentiation.Journal of clinical medicine · 2020Article
- CAD/CAM scaffolds for bone tissue engineering: investigation of biocompatibility of selective laser melted lightweight titanium.IET nanobiotechnology · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the treatment of osseous defects micro-structured three-dimensional materials for bone replacement serve as leading structure for cell migration, proliferation and bone formation. The scaffold design and culture conditions are crucial for the limited diffusion distance of nutrients and oxygen. In static culture, decreased cell activity and irregular distribution occur within the scaffold. Dynamic conditions entail physical stimulation and constant medium perfusion imitating physiological nutrient supply and metabolite disposal. Therefore, we investigated the influence of different scaffold configurations and cultivation methods on human osteoblasts. Cells were seeded on three-dimensional porous Ti-6Al-4V scaffolds manufactured with selective laser melting (SLM) or electron beam melting (EBM) varying in porosity, pore size and basic structure (cubic, diagonal, pyramidal) and cultured under static and dynamic conditions. Cell viability, migration and matrix production were examined via mitochondrial activity assay, fluorescence staining and ELISA. All scaffolds showed an increasing cell activity and matrix production under static conditions over time. Expectations about the dynamic culture were only partially fulfilled, since it enabled proliferation alike the static one and enhanced cell migration. Overall, the SLM manufactured scaffold with the highest porosity, small pore size and pyramidal basic structure proved to be the most suitable structure for cell proliferation and migration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.