Towards Tuning the Mechanical Properties of Three-Dimensional Collagen Scaffolds Using a Coupled Fiber-Matrix Model.

Shengmao Lin, Lauren A Hapach, Cynthia Reinhart-King, Linxia Gu

Abstract read

In one paragraph

Article in Materials (Basel, Switzerland), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Computational and Experimental Characterization of Aligned Collagen across Varied Crosslinking Degrees.Micromachines · 2024
Article

4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Shengmao LinDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0656, USA. linshengmao@gmail.com.

Lauren A HapachBiomedical Engineering, Cornell University, Ithaca, NY 14853, USA. lah299@cornell.edu.

Cynthia Reinhart-KingBiomedical Engineering, Cornell University, Ithaca, NY 14853, USA. cak57@cornell.edu.

Linxia GuDepartment of Mechanical and Materials Engineering, University of Nebraska-Lincoln, Lincoln, NE 68588-0656, USA. lgu@unl.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Scaffold mechanical properties are essential in regulating the microenvironment of three-dimensional cell culture. A coupled fiber-matrix numerical model was developed in this work for predicting the mechanical response of collagen scaffolds subjected to various levels of non-enzymatic glycation and collagen concentrations. The scaffold was simulated by a Voronoi network embedded in a matrix. The computational model was validated using published experimental data. Results indicate that both non-enzymatic glycation-induced matrix stiffening and fiber network density, as regulated by collagen concentration, influence scaffold behavior. The heterogeneous stress patterns of the scaffold were induced by the interfacial mechanics between the collagen fiber network and the matrix. The knowledge obtained in this work could help to fine-tune the mechanical properties of collagen scaffolds for improved tissue regeneration applications.

Indexed as

collagen concentrationcollagen scaffoldcomputational biomechanicsfiber-matrix interactionglycation

Identifiers

PMID28793511

DOI10.3390/ma8085254

PMCPMC5455520

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