ArticlePLoS neglected tropical diseases2017
Larrea tridentata: A novel source for anti-parasitic agents active against Entamoeba histolytica, Giardia lamblia and Naegleria fowleri.
Article in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of anti-Parasitology · 2021Pooled it
- Phytoextracts Used in the Treatment of Cryptosporidiosis and Giardiasis: Current State.Acta parasitologica · 2026Review
- Prevalence and species distribution of intestinal parasites: a four-year retrospective study at Burao general hospital, Somaliland.BMC research notes · 2025Article
- Article
- A Broad Spectrum Antiparasitic Activity of Organotin (IV) Derivatives and Its Untargeted Proteomic Profiling UsingPathogens (Basel, Switzerland) · 2022Article
- Phytochemical Compounds and Pharmacological Properties ofMolecules (Basel, Switzerland) · 2022Review
- Article
- Opportunistic free-living amoebal pathogens.Pathogens and global health · 2022Article
- Structure and Cytotoxicity of Novel Lignans and Lignan Glycosides from the Aerial Parts ofMolecules (Basel, Switzerland) · 2021Article
- Drug discovery for primary amebic meningoencephalitis: from screen to identification of leads.Expert review of anti-infective therapy · 2021Article
- Characterization of the antibacterial activity from ethanolic extracts of the botanical, Larrea tridentata.BMC complementary medicine and therapies · 2021Article
- Antineoplastic kinase inhibitors: A new class of potent anti-amoebic compounds.PLoS neglected tropical diseases · 2021Article
- Synthesis, Characterization, andBioMed research international · 2020Article
- Article
- Development of a Novel Ex-vivo 3D Model to Screen Amoebicidal Activity on Infected Tissue.Scientific reports · 2019Article
- Assessing the Antioxidant Properties ofMolecules (Basel, Switzerland) · 2018Article
- Identification of cysteine protease inhibitors as new drug leads against Naegleria fowleri.Experimental parasitology · 2018Article
- Flavonoids as a Natural Treatment AgainstFrontiers in cellular and infection microbiology · 2018Review
- Highly Potent 1Frontiers in cellular and infection microbiology · 2018Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Protozoan parasites infect and kill millions of people worldwide every year, particularly in developing countries where access to clean fresh water is limited. Among the most common are intestinal parasites, including Giardia lamblia and Entamoeba histolytica. These parasites wreak havoc on the epithelium lining the small intestines (G. lamblia) and colon (E. histolytica) causing giardiasis and amebiasis, respectively. In addition, there are less common but far more deadly pathogens such as Naegleria fowleri that thrive in warm waters and infect the central nervous systems of their victims via the nasal passages. Despite their prevalence and associated high mortality rates, there remains an unmet need to identify more effective therapeutics for people infected with these opportunistic parasites. To address this unmet need, we have surveyed plants and traditional herbal medicines known throughout the world to identify novel antiparasitic agents with activity against G. lamblia, E. histolytica, and N. fowleri. Herein, we report Larrea tridentata, known as creosote bush, as a novel source for secondary metabolites that display antiparasitic activity against all three pathogens. This report also characterizes the lignan compound classes, nordihydroguairetic acid and demethoxyisoguaiacin, as novel antiparasitic lead agents to further develop more effective drug therapy options for millions of people worldwide.
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