Evidence map›Paper›PMID 28793252›Full record

ArticleCell reports2017

Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease.

Ashutosh Mangalam, Shailesh K Shahi, David Luckey, Melissa Karau, Eric Marietta, Ningling Luo, Rok Seon Choung, Josephine Ju, Ramakrishna Sompallae, Katherine Gibson-Corley and 5 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
160citing papers in PubMed, 3 pooled it
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

160 citing papers in PubMed, 3 syntheses or guidelines pooled it, 264 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Journal of bacteriology · 2026
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  10. Female-enrichedbioRxiv : the preprint server for biology · 2026
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100 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Ashutosh MangalamDepartment of Immunology, Mayo Clinic, Rochester, MN 55901, USA; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: ashutosh-mangalam@uiowa.edu.
Shailesh K ShahiDepartment of Pathology, University of Iowa, Iowa City, IA 52242, USA.
David LuckeyDepartment of Immunology, Mayo Clinic, Rochester, MN 55901, USA.
Melissa KarauDivision of Clinical Microbiology, Mayo Clinic, Rochester, MN 55901, USA.
Eric MariettaDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55901, USA.
Ningling LuoDepartment of Immunology, Mayo Clinic, Rochester, MN 55901, USA.
Rok Seon ChoungDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55901, USA.
Josephine JuMayo Graduate School, Mayo Clinic, Rochester, MN, USA.
Ramakrishna SompallaeDepartment of Pathology, University of Iowa, Iowa City, IA 52242, USA; Iowa Institute of Human Genetics, University of Iowa, Iowa City, IA 52242, USA.
Katherine Gibson-CorleyDepartment of Pathology, University of Iowa, Iowa City, IA 52242, USA.
Robin PatelDivision of Clinical Microbiology, Mayo Clinic, Rochester, MN 55901, USA.
Moses RodriguezDepartment of Neurology, Mayo Clinic, Rochester, MN 55901, USA.
Chella DavidDepartment of Immunology, Mayo Clinic, Rochester, MN 55901, USA.
Veena TanejaDepartment of Immunology, Mayo Clinic, Rochester, MN 55901, USA.
Joseph MurrayDepartment of Immunology, Mayo Clinic, Rochester, MN 55901, USA; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55901, USA.
Mayo Clinic · USWinnMed · USMayo Clinic in Arizona · USUniversity of Iowa · US

Funding

MAYO CLINIC CENTER FOR TRANSLATIONAL SCIENCE ACTIVITIESUL1RR024150 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$66.4M
Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Alejandro Antonio Pezzulo · 1998 to 2026
$30.5M
Nanopore Biosensor for Kinetics of Reparative Antibodies on Plasma MembranesR01GM092993 · NIGMS · UNIVERSITY OF MINNESOTA · PI OH, SANG-HYUN · 2010 to 2013
$1.6M
Genetic Analysis of Spontaneous RemyelinationR01NS048357 · NINDS · MAYO CLINIC ROCHESTER · PI BIEBER, ALLAN JAMES · 2008 to 2011
$1.0M
Clinical Translation of a Neuron Protective Recombinant Human AntibodyR21NS073684 · NINDS · MAYO CLINIC ROCHESTER · PI RODRIGUEZ, MOSES · 2011 to 2012
$434k
NCATS NIH HHS UL1 TR000135NCRR NIH HHS UL1 RR024150NIDDK NIH HHS P30 DK054759NIGMS NIH HHS R01 GM092993NINDS NIH HHS R01 NS048357NINDS NIH HHS R21 NS073684
6 · The paper itself

Abstract

The human gut is colonized by a large number of microorganisms (∼10

Indexed as

Gastrointestinal MicrobiomeAnimalsCD4-Positive T-LymphocytesCells, CulturedDendritic CellsEncephalomyelitis, Autoimmune, ExperimentalForkhead Transcription FactorsGenes, MHC Class IIHumansMacrophagesMicePrevotellaProbioticsTh17 CellsTh1 CellsForkhead Transcription FactorsFoxp3 protein, mousedemyelinationEAEexperimental autoimmune encephalomyelitisgut microbiomehuman commensalimmunomodulationinflammationmultiple sclerosisPrevotella histicolaregulatory T cells

Identifiers

PMID28793252
PMCPMC5763484
OpenAlexW2743852004

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.