Evidence map›Paper›PMID 28793058›Full record

ArticleBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2017

Inflammation and oxidative stress in heart failure: effects of exercise intensity and duration.

G A Ribeiro-Samora, L A Rabelo, A C C Ferreira, M Favero, G S Guedes, L S M Pereira, V F Parreira, R R Britto

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
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  7. Exercise intensity and cardiac metabolic adaptations in elderly heart failure rehabilitation: A review.International journal of cardiology. Cardiovascular risk and prevention · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

G A Ribeiro-SamoraPrograma de Pós-Graduação em Ciências da Reabilitação, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
L A RabeloLaboratório de Reatividade Cardiovascular, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brasil.
A C C FerreiraDepartamento de Fisioterapia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
M FaveroDepartamento de Fisioterapia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
G S GuedesLaboratório de Reatividade Cardiovascular, Instituto de Ciências Biológicas e da Saúde, Universidade Federal de Alagoas, Maceió, AL, Brasil.
L S M PereiraDepartamento de Fisioterapia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
V F ParreiraDepartamento de Fisioterapia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
R R BrittoDepartamento de Fisioterapia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais · BRUniversidade Federal de Alagoas · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although acute exercise is apparently pro-inflammatory and increases oxidative stress, it can promote the necessary stress stimulus to train chronic adaptations in patients with chronic heart failure (CHF). This study aimed to compare the effects of exercise intensity and duration on the inflammatory markers soluble tumor necrosis factor receptor (sTNFR1) and interleukin-6 (IL-6), and on oxidative stress [malondialdehyde (MDA) and antioxidant enzymes: catalase (CAT) and superoxide dismutase (SOD)] in individuals with CHF. Eighteen patients performed three exercise sessions: 30 min of moderate-intensity (M30) exercise, 30 min of low-intensity (L30) exercise, and 45 min of low-intensity (L45) exercise. Blood analysis was performed before exercise (baseline), immediately after each session (after), and 1 h after the end of each session (1h after). Thirty min of M30 exercise promoted a larger stressor stimulus, both pro-inflammatory and pro-oxidative, than that promoted by exercises L30 and L45. This was evidenced by increased sTNFR1 and MDA levels after exercise M30. In response to this stressor stimulus, 1 h after exercise, there was an increase in IL-6 and CAT levels, and a return of sTNFR1 to baseline levels. These findings suggest that compared with the duration of exercise, the exercise intensity was an important factor of physiologic adjustments.

Indexed as

Exercise TestAdultBiomarkersCatalaseChronic DiseaseFemaleHeart FailureHumansInflammationInterleukin-6MaleMalondialdehydeMiddle AgedOxidative StressReceptors, Tumor Necrosis FactorSuperoxide DismutaseBiomarkersCatalaseIL6 protein, humanInterleukin-6MalondialdehydeReceptors, Tumor Necrosis FactorSuperoxide Dismutase

Identifiers

PMID28793058
PMCPMC5572846
OpenAlexW2743729117

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.