ArticlePloS one2017
Is intraindividual reaction time variability an independent cognitive predictor of mortality in old age? Findings from the Sydney Memory and Ageing Study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Trial
- Autistic Trait Level and Reaction Time in Older Adults: The Influence of Sex and Task upon Study Outcome.Autism in adulthood · 2026Article
- Capturing trial-by-trial variability in behaviour: people with Parkinson's disease exhibit a greater rate of short-term fluctuations in response times.Translational psychiatry · 2025Article
- Limited Evidence to Review-Is There an Association Between Cognition and Upper Extremity Motor Reaction Time in Older Adults?NeuroSci · 2025Review
- Correlation of cognitive impairment with Mediterranean diet and mortality: a prospective cohort study.Frontiers in aging neuroscience · 2025Article
- Monitoring reaction time to digital device in the very-old to detect early cognitive decline.npj aging · 2024Article
- Fluctuations of Attention During Self-paced Naturalistic Goal-Directed Behavior in Attention-Deficit/Hyperactivity Disorder.JAACAP open · 2024Article
- Increased intraindividual variability in reaction time performance is associated with emerging cognitive decline in cognitively unimpaired adults.Neuropsychology · 2024Article
- Modeling Risk Factors for Intraindividual Variability: A Mixed-Effects Beta-Binomial Model Applied to Cognitive Function in Older People in the English Longitudinal Study of Ageing.American journal of epidemiology · 2024Article
- Moving intra-individual variability (IIV) towards clinical utility: IIV measured using a commercial testing platform.Journal of the neurological sciences · 2023Article
- Assessing Healthy Aging Score and Its Association With All-Cause Mortality: Findings From the China Health and Retirement Longitudinal Study.Innovation in aging · 2023Article
- Within-subject reaction time variability: Role of cortical networks and underlying neurophysiological mechanisms.NeuroImage · 2021Article
- Brain training using cognitive apps can improve cognitive performance and processing speed in older adults.Scientific reports · 2021Article
- The Applicability of the Poincaré Plot in the Analysis of Variability of Reaction Time during Serial Testing.International journal of environmental research and public health · 2021Observational
- Lacking Pace but Not Precision: Age-Related Information Processing Changes in Response to a Dynamic Attentional Control Task.Brain sciences · 2020Article
- Cognitive Function and Mortality: Results from Kaunas HAPIEE Study 2006-2017.International journal of environmental research and public health · 2020Article
- Associations between cardiorespiratory fitness, physical activity, intraindividual variability in behavior, and cingulate cortex in younger adults.Journal of sport and health science · 2019Article
- Sequential Information Processing: The "Elevated First Response Effect" Can Contribute to Exaggerated Intra-Individual Variability in Older Adults.The Yale journal of biology and medicine · 2019Article
- Subcortical Ischemic Vascular Cognitive Impairment: Insights from Reaction Time Measures.Journal of Alzheimer's disease : JAD · 2019Article
- Small samples and increased variability - discussing the need for restricted types of randomization in exercise interventions in old age.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2019Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Intraindividual variability of reaction time (IIVRT), a proposed cognitive marker of neurobiological disturbance, increases in old age, and has been associated with dementia and mortality. The extent to which IIVRT is an independent predictor of mortality, however, is unclear. This study investigated the association of IIVRT and all-cause mortality while accounting for cognitive level, incident dementia and biomedical risk factors in 861 participants aged 70-90 from the Sydney Memory and Ageing Study. Participants completed two computerised reaction time (RT) tasks (76 trials in total) at baseline, and comprehensive medical and neuropsychological assessments every 2 years. Composite RT measures were derived from the two tasks-the mean RT and the IIVRT measure computed from the intraindividual standard deviation of the RTs (with age and time-on-task effects partialled out). Consensus dementia diagnoses were made by an expert panel of clinicians using clinical criteria, and mortality data were obtained from a state registry. Cox proportional hazards models estimated the association of IIVRT and mean RT with survival time over 8 years during which 191 (22.2%) participants died. Greater IIVRT but not mean RT significantly predicted survival time after adjusting for age, sex, global cognition score, cardiovascular risk index and apolipoprotein ɛ4 status. After excluding incident dementia cases, the association of IIVRT with mortality changed very little. Our findings suggest that greater IIVRT uniquely predicts shorter time to death and that lower global cognition and prodromal dementia in older individuals do not explain this relationship.
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