Evidence map›Paper›PMID 28792943›Full record

ArticlePloS one2017

Discovery of Aspergillus frankstonensis sp. nov. during environmental sampling for animal and human fungal pathogens.

Jessica J Talbot, Jos Houbraken, Jens C Frisvad, Robert A Samson, Sarah E Kidd, John Pitt, Sue Lindsay, Julia A Beatty, Vanessa R Barrs

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 20 citations in OpenAlex.

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  5. Antimicrobial agents and chemotherapy · 2019
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  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Jessica J TalbotSydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camperdown, New South Wales, Australia.
Jos HoubrakenWesterdijk Fungal Biodiversity Institute, Utrecht, Netherlands.
Jens C FrisvadDepartment of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark.
Robert A SamsonWesterdijk Fungal Biodiversity Institute, Utrecht, Netherlands.
Sarah E KiddNational Mycology Reference Centre, Microbiology and Infectious Diseases, SA Pathology, Adelaide, South Australia, Australia.
John PittCSIRO Food Science, CSIRO, North Ryde, New South Wales, Australia.
Sue LindsayFaculty of Science and Engineering, Macquarie University, North Ryde, New South Wales, Australia.
Julia A BeattySydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camperdown, New South Wales, Australia.
Vanessa R BarrsSydney School of Veterinary Science, Faculty of Science, The University of Sydney, Camperdown, New South Wales, Australia.ORCID http://orcid.org/0000-0001-6761-8022
The University of Sydney · AUWesterdijk Fungal Biodiversity Institute · NLCommonwealth Scientific and Industrial Research Organisation · AUMacquarie University · AUSouth Australia Pathology · AUTechnical University of Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Invasive fungal infections (IFI) due to species in Aspergillus section Fumigati (ASF), including the Aspergillus viridinutans species complex (AVSC), are increasingly reported in humans and cats. The risk of exposure to these medically important fungi in Australia is unknown. Air and soil was sampled from the domiciles of pet cats diagnosed with these IFI and from a nature reserve in Frankston, Victoria, where Aspergillus viridinutans sensu stricto was discovered in 1954. Of 104 ASF species isolated, 61% were A. fumigatus sensu stricto, 9% were AVSC (A. felis-clade and A. frankstonensis sp. nov.) and 30% were other species (30%). Seven pathogenic ASF species known to cause disease in humans and animals (A. felis-clade, A. fischeri, A. thermomutatus, A. lentulus, A. laciniosus A. fumisynnematus, A. hiratsukae) comprised 25% of isolates overall. AVSC species were only isolated from Frankston soil where they were abundant, suggesting a particular ecological niche. Phylogenetic, morphological and metabolomic analyses of these isolates identified a new species, A. frankstonensis that is phylogenetically distinct from other AVSC species, heterothallic and produces a unique array of extrolites, including the UV spectrum characterized compounds DOLD, RAIMO and CALBO. Shared morphological and physiological characteristics with other AVSC species include slow sporulation, optimal growth at 37°C, no growth at 50°C, and viriditoxin production. Overall, the risk of environmental exposure to pathogenic species in ASF in Australia appears to be high, but there was no evidence of direct environmental exposure to AVSC species in areas where humans and cats cohabitate.

Indexed as

AnimalsAntifungal AgentsAspergillosisAspergillusAustraliaBase SequenceCatsDNA, FungalEnvironmental ExposureEnvironmental MonitoringHumansInvasive Fungal InfectionsMicrobial Sensitivity TestsNaphtholsPhylogenySequence Analysis, DNAAntifungal AgentsDNA, FungalNaphtholsviriditoxin

Identifiers

PMID28792943
PMCPMC5549889
OpenAlexW2744431204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.