ArticleNature2017
Mutation predicts 40 million years of fly wing evolution.
Article in Nature, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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Who cites it
67 citing papers in PubMed, 237 citations in OpenAlex.
- Apparent stabilizing selection explains micro- and macroevolution of Drosophila wings.Nature ecology & evolution · 2026Article
- Persistent selection on size explains micro- and macroevolutionary alignments in fly wings.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Stabilizing and directional selection shape the genetic variation of gene expression in the transcriptome of Chlamydomonas.Molecular biology and evolution · 2026Article
- Evolution of crop phenotypic spaces through domestication.The New phytologist · 2026Article
- A century of theories of balancing selection.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Neural crest cell biology shapes lizard skull evolution across evolutionary time scales.Evolution letters · 2026Article
- Bridging developmental and statistical approaches to variation and evolution.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Evolvability: progress and key questions.Bioscience · 2025Review
- Developmentally cascading structures do not lose evolutionary potential, but compound developmental instability in rat molars.bioRxiv : the preprint server for biology · 2025Article
- Developmental lines of least resistance predict standing genetic covariation but do not constrain plasticity or rapid evolution.Proceedings. Biological sciences · 2025Article
- Evolution of developmental bias explains divergent patterns of phenotypic evolution in two nematode clades.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Conserved wing shape variation across biological scales unveils dialectical relationships between micro- and macroevolution.Communications biology · 2025Article
- Alternative Mutational Architectures Producing Identical M-Matrices can Lead to Different Patterns of Evolutionary Divergence.Genome biology and evolution · 2025Article
- Macroevolution along developmental lines of least resistance in fly wings.Nature ecology & evolution · 2025Article
- Unifying approaches from statistical genetics and phylogenetics for mapping phenotypes in structured populations.PLoS biology · 2024Article
- Developmental noise and phenotypic plasticity are correlated inEvolution letters · 2024Article
- Utilizing developmental dynamics for evolutionary prediction and control.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Patterned apoptosis has an instructive role for local growth and tissue shape regulation in a fast-growing epithelium.Current biology : CB · 2024Article
- Developmental bias as a cause and consequence of adaptive radiation and divergence.Frontiers in cell and developmental biology · 2024Review
- The evolution of genetic covariance and modularity as a result of multigenerational environmental fluctuation.Evolution letters · 2023Article
7 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutation enables evolution, but the idea that adaptation is also shaped by mutational variation is controversial. Simple evolutionary hypotheses predict such a relationship if the supply of mutations constrains evolution, but it is not clear that constraints exist, and, even if they do, they may be overcome by long-term natural selection. Quantification of the relationship between mutation and phenotypic divergence among species will help to resolve these issues. Here we use precise data on over 50,000 Drosophilid fly wings to demonstrate unexpectedly strong positive relationships between variation produced by mutation, standing genetic variation, and the rate of evolution over the last 40 million years. Our results are inconsistent with simple constraint hypotheses because the rate of evolution is very low relative to what both mutational and standing variation could allow. In principle, the constraint hypothesis could be rescued if the vast majority of mutations are so deleterious that they cannot contribute to evolution, but this also requires the implausible assumption that deleterious mutations have the same pattern of effects as potentially advantageous ones. Our evidence for a strong relationship between mutation and divergence in a slowly evolving structure challenges the existing models of mutation in evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.