Evidence map›Paper›PMID 28792616›Full record

ArticleAlcoholism, clinical and experimental research2017

Proteomic Profiling of Liver and Plasma in Chronic Ethanol Feeding Model of Hepatic Alcohol Dehydrogenase-Deficient Deer Mice.

Kamlesh K Bhopale, Samir M Amer, Lata Kaphalia, Kizhake V Soman, John E Wiktorowicz, Ghulam A Shakeel Ansari, Bhupendra S Kaphalia

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alcoholism, clinical and experimental research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 12 citations in OpenAlex.

  1. The Role of Mitochondrial Complexes in Liver Diseases.Journal of clinical and translational hepatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Kamlesh K BhopaleDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas.
Samir M AmerDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas.
Lata KaphaliaDepartment of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas.
Kizhake V SomanDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas.
John E WiktorowiczDepartment of Biochemistry and Molecular Biology, The University of Texas Medical Branch, Galveston, Texas.
Ghulam A Shakeel AnsariDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas.
Bhupendra S KaphaliaDepartment of Pathology, The University of Texas Medical Branch, Galveston, Texas.
The University of Texas Medical Branch at Galveston · USTanta University · EG

Funding

Synthetic Organic Chemistry CoreP30ES006676 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ELFERINK, CORNELIS JOHAN · 1995 to 2017
$21.7M
Role of Alcohol Metabolism in Alcoholic Chronic PancreatitisR01AA025850 · NIAAA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KAPHALIA, BHUPENDRA S · 2017 to 2021
$1.7M
AMPK Signaling and Chronic Alcoholic PancreatitisR21AA024699 · NIAAA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI KAPHALIA, BHUPENDRA S · 2016 to 2017
$407k
NIAAA NIH HHS R01 AA025850NIAAA NIH HHS R21 AA024699NIEHS NIH HHS P30 ES006676
6 · The paper itself

Abstract

backgroundChronic alcohol abuse, a major risk factor for such diseases as hepatitis and cirrhosis, impairs hepatic alcohol dehydrogenase (ADH; key ethanol [EtOH]-metabolizing enzyme). Therefore, differentially altered hepatic and plasma proteomes were identified in chronic EtOH feeding model of hepatic ADH-deficient (ADH

methodsADH

resultsHistology of the liver showed panlobular steatosis and infiltration of T lymphocytes. Using the criteria of ≥1.5 for fold change (p-value ≤0.05) with expectation value (E ≤10

conclusionsChronic EtOH feeding in ADH

Indexed as

Alcohol DehydrogenaseAnimalsEthanolLiverLiver Diseases, AlcoholicMaleMicePeromyscusProteomicsAlcohol DehydrogenaseEthanolDeer MiceEthanolLiverPlasmaProteomics

Identifiers

PMID28792616
PMCPMC5626632
OpenAlexW2744308877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.