Evidence map›Paper›PMID 28792356›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018

Kinetic evaluation and test-retest reproducibility of [

Sjoerd J Finnema, Nabeel B Nabulsi, Joël Mercier, Shu-Fei Lin, Ming-Kai Chen, David Matuskey, Jean-Dominique Gallezot, Shannan Henry, Jonas Hannestad, Yiyun Huang and 1 more

2 registry-linked trialsOpen access · bronzeAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 148 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
148citing papers in PubMed, 5 pooled it
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04038840 phase1recruitingnot on this mapstarted 2019, after this paper: background citation

Imaging Synapses With [11C] UCB-J in the Human Brain

TypeinterventionalSponsorDavidzon, Guido, M.D.Ran2019 to 2025Enrolled60ConditionsSchizophreniaArms[11C]UCB-J radiotracer, PET-MR
NCT04311619 phase1withdrawnnot on this mapstarted 2019, after this paper: background citation

Does Repetitive Transcranial Magnetic Stimulation (rTMS) Induce Synaptic Plasticity?

TypeinterventionalSponsorDavidzon, Guido, M.D.Ran2019 to 2025Enrolled0ConditionsMajor Depressive DisorderArms[11C]UCB-J radiotracer, PET-MR
3 · Its place in the literature

Who cites it

148 citing papers in PubMed, 5 syntheses or guidelines pooled it, 220 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Changes in synaptic density in the subacute phase after ischemic stroke: AJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Trial
  9. First-in-Human Evaluation ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Trial
  10. Article
  11. Article
  12. Article
  13. Article
  14. Fully Automated Azeotropic Drying-Free Synthesis of [Molecules (Basel, Switzerland) · 2026
    Article
  15. Review
  16. Article
  17. Article
  18. Noninvasive Quantification of [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  19. Whole brain grey matter synaptic terminal density, age and intellectual functioning in schizophrenia: an in vivo [Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  20. Article

88 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Sjoerd J Finnema1 Department of Radiology and Biomedical Imaging, Yale Positron Emission Tomography Center, Yale University, New Haven, CT, USA.ORCID 0000-0002-4972-3627
Nabeel B Nabulsi1 Department of Radiology and Biomedical Imaging, Yale Positron Emission Tomography Center, Yale University, New Haven, CT, USA.
Joël Mercier2 UCB Pharma, B-1420 Braine-l'Alleud, Belgium.
Shu-Fei Lin1 Department of Radiology and Biomedical Imaging, Yale Positron Emission Tomography Center, Yale University, New Haven, CT, USA.
Ming-Kai Chen1 Department of Radiology and Biomedical Imaging, Yale Positron Emission Tomography Center, Yale University, New Haven, CT, USA.
David Matuskey1 Department of Radiology and Biomedical Imaging, Yale Positron Emission Tomography Center, Yale University, New Haven, CT, USA.
Jean-Dominique Gallezot1 Department of Radiology and Biomedical Imaging, Yale Positron Emission Tomography Center, Yale University, New Haven, CT, USA.
Shannan Henry1 Department of Radiology and Biomedical Imaging, Yale Positron Emission Tomography Center, Yale University, New Haven, CT, USA.
Jonas Hannestad2 UCB Pharma, B-1420 Braine-l'Alleud, Belgium.
Yiyun Huang1 Department of Radiology and Biomedical Imaging, Yale Positron Emission Tomography Center, Yale University, New Haven, CT, USA.
Richard E Carson1 Department of Radiology and Biomedical Imaging, Yale Positron Emission Tomography Center, Yale University, New Haven, CT, USA.
Yale University · USUCB Pharma (Belgium) · BE

Funding

Yale University Clinical and Translational Science Award ProgramUL1TR000142 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$31.8M
SV2A PET Imaging in Healthy Subjects and Epilepsy PatientsR01NS094253 · NINDS · YALE UNIVERSITY · PI CARSON, RICHARD E. · 2016 to 2020
$2.8M
NCATS NIH HHS UL1 TR000142NINDS NIH HHS R01 NS094253
6 · The paper itself

Abstract

Synaptic vesicle glycoprotein 2A (SV2A) is ubiquitously present in presynaptic terminals. Here we report kinetic modeling and test-retest reproducibility assessment of the SV2A positron emission tomography (PET) radioligand [

Indexed as

AdultBrainCarbon RadioisotopesFemaleHumansKineticsMaleMembrane GlycoproteinsMiddle AgedNerve Tissue ProteinsNeuroimagingPositron-Emission TomographyPyridinesPyrrolidinesPyrrolidinonesRadiopharmaceuticals1-((3-(methylpyridin-4-yl)methyl)-4-(3,4,5-trifluorophenyl)pyrrolidin-2-oneCarbon RadioisotopesMembrane GlycoproteinsNerve Tissue ProteinsPyridinesPyrrolidinesPyrrolidinonesRadiopharmaceuticalsSV2A protein, humanBrain imagingkinetic modelingneurodegenerationpositron emission tomographysynapses/dendrites

Identifiers

PMID28792356
PMCPMC6259313
OpenAlexW2742230759

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.