ReviewJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2018
Oxygen metabolism in acute ischemic stroke.
Review in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Tale of Two Cities: narrative review of oxygen.F1000Research · 2023Pooled it
- Intra-arterial selective hypothermia for acute ischemic stroke neuroprotection: A multicenter pilot trial in China.PLoS medicine · 2025Trial
- The Role of 100% Oxygen in the Resuscitation and Neurologic Recovery of Neonates Born with Perinatal Depression and Arrested Circulation.The Journal of pediatrics · 2026Article
- Oxygen extraction fraction mapping between normal cognition and mild cognitive impairment in older adults using quantitative BOLD.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- Article
- Ranolazine neuroprotection against middle cerebral artery occlusion/reperfusion ischemic injury via modulation of brain-derived neurotrophic factor and brain mitochondrial tu translation elongation factor (TUFM).Metabolic brain disease · 2025Article
- Dual-modal metabolic analysis reveals hypothermia-reversible uncoupling of oxidative phosphorylation in neonatal brain hypoxia-ischemia.bioRxiv : the preprint server for biology · 2025Article
- The Brush Sign Is Associated with a More Severe Oxygen Metabolic Impairment of the Ischemic Penumbra: An MRI-Based Study in Patients with Acute Stroke.AJNR. American journal of neuroradiology · 2025Observational
- The impact of isoflurane anesthesia on brain metabolism in mice: An MRI and electroencephalography study.NMR in biomedicine · 2024Article
- Chronic hypertension alters the relationship between collateral blood flow cortical cerebral blood flow, and brain tissue oxygenation.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke.Aging and disease · 2024Article
- Quantification of Infarct Core Volume in Patients with Acute Ischemic Stroke Using Cerebral Metabolic Rate of Oxygen in CT Perfusion.AJNR. American journal of neuroradiology · 2024Article
- Quantitative Optical Imaging of Oxygen in Brain Vasculature.The journal of physical chemistry. B · 2024Review
- Nanomaterial-related hemoglobin-based oxygen carriers, with emphasis on liposome and nano-capsules, for biomedical applications: current status and future perspectives.Journal of nanobiotechnology · 2024Review
- Correlation between obstructive sleep apnea and hypoperfusion in patients with acute cerebral infarction.Frontiers in neurology · 2024Article
- Vascular space occupancy asymmetric spin echo (VASO-ASE) for non-invasive quantification of cerebral oxygen extraction fraction.Magnetic resonance in medicine · 2023Article
- Assessing Cerebral Oxygen Metabolism Changes in Patients With Preeclampsia Using Voxel-Based Morphometry of Oxygen Extraction Fraction Maps in Magnetic Resonance Imaging.Korean journal of radiology · 2023Article
- Three-dimensional non-invasive brain imaging of ischemic stroke by integrated photoacoustic, ultrasound and angiographic tomography (PAUSAT).Photoacoustics · 2023Article
- The BE COOL Treatments (Batroxobin, oxygEn, Conditioning, and cOOLing): Emerging Adjunct Therapies for Ischemic Cerebrovascular Disease.Journal of clinical medicine · 2022Review
- Neuroimaging Methods to Map In Vivo Changes of OXPHOS and Oxidative Stress in Neurodegenerative Disorders.International journal of molecular sciences · 2022Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gaining insights into brain oxygen metabolism has been one of the key areas of research in neurosciences. Extensive efforts have been devoted to developing approaches capable of providing measures of brain oxygen metabolism not only under normal physiological conditions but, more importantly, in various pathophysiological conditions such as cerebral ischemia. In particular, quantitative measures of cerebral metabolic rate of oxygen using positron emission tomography (PET) have been shown to be capable of discerning brain tissue viability during ischemic insults. However, the complex logistics associated with oxygen-15 PET have substantially hampered its wide clinical applicability. In contrast, magnetic resonance imaging (MRI)-based approaches have provided quantitative measures of cerebral oxygen metabolism similar to that obtained using PET. Given the wide availability, MRI-based approaches may have broader clinical impacts, particularly in cerebral ischemia, when time is a critical factor in deciding treatment selection. In this article, we review the pathophysiological basis of altered cerebral hemodynamics and oxygen metabolism in cerebral ischemia, how quantitative measures of cerebral metabolism were obtained using the Kety-Schmidt approach, the physical concepts of non-invasive oxygen metabolism imaging approaches, and, finally, clinical applications of the discussed imaging approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.