Evidence map›Paper›PMID 28792122›Full record

ArticleStem cells translational medicine2017

Acceleration of Fracture Healing by Overexpression of Basic Fibroblast Growth Factor in the Mesenchymal Stromal Cells.

Hongliang Zhang, Alexander Kot, Yu-An E Lay, Fernando A Fierro, Haiyan Chen, Nancy E Lane, Wei Yao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Hongliang ZhangCenter for Musculoskeletal Health, Department of Internal Medicine, Sacramento, California, USA.
Alexander KotCenter for Musculoskeletal Health, Department of Internal Medicine, Sacramento, California, USA.
Yu-An E LayCenter for Musculoskeletal Health, Department of Internal Medicine, Sacramento, California, USA.
Fernando A FierroStem Cell Program, UC Davis Health System, Institute for Regenerative Cures, University of California Davis Medical Center, Sacramento, California, USA.ORCID 0000-0002-1086-2646
Haiyan ChenCenter for Musculoskeletal Health, Department of Internal Medicine, Sacramento, California, USA.
Nancy E LaneCenter for Musculoskeletal Health, Department of Internal Medicine, Sacramento, California, USA.
Wei YaoCenter for Musculoskeletal Health, Department of Internal Medicine, Sacramento, California, USA.ORCID 0000-0002-1198-1161
Institute for Musculoskeletal Health · AUCalifornia Institute for Regenerative Medicine · USSecond Xiangya Hospital of Central South University · CN

Funding

Sex Differences in response to an exercise for hyperkyphosisP50AR063043 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI KATZMAN, WENDY BETH · 2012 to 2017
$5.7M
Directing mesenchymal stem cells to bone to augment bone formationR01AR061366 · NIAMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI YAO, WEI · 2012 to 2015
$1.1M
NIAMS NIH HHS P50 AR063043NIAMS NIH HHS R01 AR061366
6 · The paper itself

Abstract

In this study, we engineered mesenchymal stem cells (MSCs) to over-express basic fibroblast growth factor (bFGF) and evaluated its effects on fracture healing. Adipose-derived mouse MSCs were transduced to express bFGF and green fluorescence protein (ADSC

Indexed as

Fracture HealingAdipose TissueAnimalsCells, CulturedFibroblast Growth Factor 2Mesenchymal Stem CellsMesenchymal Stem Cell TransplantationMiceOsteoblastsOsteogenesisUp-RegulationVascular Endothelial Growth Factor AFibroblast Growth Factor 2Vascular Endothelial Growth Factor ABasic fibroblast growth factorBone strengthCallusMesenchymal stromal cellsOsteoblasts

Identifiers

PMID28792122
PMCPMC6430058
OpenAlexW2742952428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.