Evidence map›Paper›PMID 28792090›Full record

ArticleMolecular microbiology2017

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs.

Emma Louise Meredith, Ambika Kumar, Aya Konno, Joanna Szular, Sam Alsford, Karin Seifert, David Horn, Shane R Wilkinson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular microbiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Emma Louise MeredithSchool of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Ambika KumarSchool of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Aya KonnoSchool of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Joanna SzularSchool of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Sam AlsfordDepartment of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
Karin SeifertDepartment of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, Keppel Street, London, UK.
David HornThe Wellcome Trust Centre for Anti-Infectives Research, School of Life Sciences, University of Dundee, Dundee, UK.ORCID http://orcid.org/0000-0001-5173-9284
Shane R WilkinsonSchool of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.ORCID http://orcid.org/0000-0002-8474-1943
Queen Mary University of London · GBUniversity of London · GBUniversity of Dundee · GB

Funding

Medical Research Council MR/J008702/1Wellcome Trust 203134/Z/16/Z
6 · The paper itself

Abstract

Quinone-based compounds have been exploited to treat infectious diseases and cancer, with such chemicals often functioning as inhibitors of key metabolic pathways or as prodrugs. Here, we screened an aziridinyl 1,4-benzoquinone (ABQ) library against the causative agents of trypanosomiasis, and cutaneous leishmaniasis, identifying several potent structures that exhibited EC

Indexed as

AnimalsAziridinesBenzoquinonesDNADNA DamageHumansNADPH-Ferrihemoprotein ReductaseNitroreductasesProdrugsStructure-Activity RelationshipTrypanocidal AgentsTrypanosoma brucei bruceiTrypanosoma cruziaromatic NADH-dependent nitroreductaseaziridineAziridinesBenzoquinonesDNANADPH-Ferrihemoprotein ReductaseNitroreductasesProdrugsquinoneTrypanocidal Agents

Identifiers

PMID28792090
PMCPMC5656836
OpenAlexW2743392991

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.