Evidence map›Paper›PMID 28792011›Full record

ArticleThe Journal of antibiotics2017

F-36316 A and B, novel vasoactive compounds, isolated from Incrucipulum sp. SANK 10414.

Yuki Hirota-Takahata, Yoko Ishimoto, Emi Kurosawa, Yuko Iwadate, Yoshiko Onozawa, Isshin Tanaka, Masahiro Tanaka, Hideki Kobayashi

Abstract read
PubMed Publisher
In one paragraph

Article in The Journal of antibiotics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuki Hirota-TakahataOrganic Synthesis Department, Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Yoko IshimotoFrontier Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Emi KurosawaOrganic Synthesis Department, Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Yuko IwadateOrganic Synthesis Department, Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Yoshiko OnozawaFrontier Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.
Isshin TanakaOrganic Synthesis Department, Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Masahiro TanakaOrganic Synthesis Department, Daiichi Sankyo RD Novare Co., Ltd, Tokyo, Japan.
Hideki KobayashiFrontier Research Laboratories, Daiichi Sankyo Co., Ltd, Tokyo, Japan.ORCID http://orcid.org/0000-0002-3650-9154

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the course of our screening program for vasoactive compounds using co-culture assay of endothelial cells and fibroblast cells, potent activity was detected in the cultured broth of Incrucipulum sp. SANK 10414. Two active compounds, F-36316 A and B, and a non-active homolog, F-36316 C, were isolated from the broth. The structures of F-36316 A, B and C were elucidated by physicochemical data and spectral analyses, and found to be new 3-acylated tetronic acid homologs. F-36316 A and B induced morphological changes of endothelial cells different from vascular endothelial growth factor (VEGF) or vestaines in the assay with EC

Indexed as

AnimalsAscomycotaBiological ProductsCapillary PermeabilityCoculture TechniquesCulture MediaEndothelial CellsFibroblastsMice, Inbred C57BLSpectrum AnalysisBiological ProductsCulture Media

Identifiers

PMID28792011

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.