Evidence map›Paper›PMID 28792003›Full record

ArticleMucosal immunology2018

Vaccine-modified NF-kB and GR signaling in cervicovaginal epithelium correlates with protection.

L Shang, A J Smith, C S Reilly, L Duan, K E Perkey, S Wietgrefe, M Zupancic, P J Southern, R P Johnson, J V Carlis and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mucosal immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

L ShangDepartment of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
A J SmithDepartment of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
C S ReillyDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
L DuanDepartment of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
K E PerkeyDepartment of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
S WietgrefeDepartment of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
M ZupancicDepartment of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
P J SouthernDepartment of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
R P JohnsonYerkes National Primate Research Center, Emory University, Atlanta, Georgia, USA.
J V CarlisDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
A T HaaseDepartment of Microbiology and Immunology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.
University of Minnesota Medical Center · USUniversity of Minnesota · USEmory University · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
ZETA CHAIN OF T CELL RECEPTOR INTERACTS W/ NEF OF SIV &HIV2P51RR000168 · NCRR · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WESTMORELAND, SUSAN V. · 1985 to 2011
$139.3M
Pathology and Veterinary Service CoreP01AI071306 · NIAID · HARVARD MEDICAL SCHOOL · PI JOHNSON, R. PAUL · 2007 to 2011
$18.3M
MOUSE MODELS OF CANCER, BONE DISEASE, AND LACTATIONK26RR000168 · NCRR · OHIO STATE UNIVERSITY · PI ROSOL, THOMAS J · 2000 to 2004
$547k
CCR NIH HHS HHSN261200800001CNCI NIH HHS HHSN261200800001ENCRR NIH HHS K26 RR000168NCRR NIH HHS P51 RR000168NIAID NIH HHS P01 AI071306NIH HHS P51 OD011132
6 · The paper itself

Abstract

Cervicovaginal epithelium plays a critical role in determining the outcome of virus transmission in the female reproductive tract (FRT) by initiating or suppressing transmission-facilitating mucosal immune responses in naïve and SIVmac239Δnef-vaccinated animals, respectively. In this study, we examined the very early responses of cervical epithelium within 24 h after vaginal exposure to SIV in naive and SIVmac239Δnef-vaccinated rhesus macaques. Using both ex vivo and in vivo experimental systems, we found that vaginal exposure to SIV rapidly induces a broad spectrum of pro-inflammatory responses in the epithelium associated with a reciprocal regulation of NF-kB and glucocorticoid receptor (GR) signaling pathways. Conversely, maintenance of high-level GR expression and suppression of NF-kB expression in the epithelium were associated with an immunologically quiescent state in the FRT mucosa and protection against vaginal challenge in SIVmac239Δnef-vaccinated animals. We show that the immunologically quiescent state is induced by FCGR2B-immune complexes interactions that modify the reciprocal regulation of NF-kB and GR signaling pathways. Our results suggest that targeting the balance of NF-kB and GR signaling in early cervicovaginal epithelium responses could moderate mucosal inflammation and target cell availability after vaginal infection, thereby providing a complementary approach to current prevention strategies.

Indexed as

AIDS VaccinesAnimalsAntibodies, ViralAspartic Acid EndopeptidasesCervix UteriDisease Transmission, InfectiousEpithelial CellsFemaleHIV-1HIV InfectionsImmunity, MucosalInflammationMacaca mulattaNF-kappa BReceptors, GlucocorticoidSAIDS VaccinesAIDS VaccinesAntibodies, ViralAspartic Acid EndopeptidasesNF-kappa BReceptors, GlucocorticoidSAIDS VaccinesSIV(mac) proteinaseViral Vaccines

Identifiers

PMID28792003
PMCPMC5807226
OpenAlexW2742954108

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.