Evidence map›Paper›PMID 28791759›Full record

ArticleJournal of magnetic resonance imaging : JMRI2018

Spatial distribution of flow and oxygenation in the cerebral venous drainage system.

Jill B De Vis, Hanzhang Lu, Harshan Ravi, Jeroen Hendrikse, Peiying Liu

Abstract read
In one paragraph

Article in Journal of magnetic resonance imaging : JMRI, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. The dependence of COImaging neuroscience (Cambridge, Mass.) · 2025
    Article
  5. COJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024
    Article
  6. Article
  7. Article
  8. Metabolism of oxygen via TMagnetic resonance in medicine · 2022
    Article
  9. Review
  10. Observational
  11. Article
  12. Article
  13. Article
  14. In vivo validation of T2- and susceptibility-based SMagnetic resonance in medicine · 2019
    Article
  15. Article
  16. Understanding jugular venous outflow disturbance.CNS neuroscience & therapeutics · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Jill B De VisDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Hanzhang LuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Harshan RaviCenter for Neuroscience and Regenerative Medicine, National Institutes of Health, Bethesda, Maryland, USA.
Jeroen HendrikseDepartment of Radiology, University Medical Center Utrecht, The Netherlands.
Peiying LiuDepartment of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USNational Institutes of Health · USUniversity Medical Center Utrecht · NL

Funding

Normalized functional MRI in human brain disordersR01MH084021 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2008 to 2017
$3.6M
BOLD and its discontents: age-differences in the neurophysiology of fMRI signalR01AG047972 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG, RYPMA, BART · 2015 to 2019
$1.7M
Cognition and cerebrovascular function across the lifespanR01AG042753 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI LU, HANZHANG · 2013 to 2015
$841k
Advanced MRI methods to image vascular physiology with respiratory manipulationsR21NS095342 · NINDS · JOHNS HOPKINS UNIVERSITY · PI LU, HANZHANG · 2016 to 2017
$476k
Quantification of brain metabolic rate in neonates using MRIR21NS085634 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI LIU, PEIYING · 2014 to 2015
$441k
European Research Council 637024NIA NIH HHS R01 AG042753NIA NIH HHS R01 AG047972NIMH NIH HHS R01 MH084021NINDS NIH HHS R21 NS085634NINDS NIH HHS R21 NS095342
6 · The paper itself

Abstract

purposeTo investigate the venous oxygenation and flow in the brain, and determine how they might change under challenged states. MATERIALS AND

methodsEight healthy human subjects (24-37 years) were studied. T

resultsVenous oxygenation in the SSS, the SS, and the IJVs was 61 ± 4%, 64 ± 4%, and 62 ± 4%, respectively, at room air, and increased to 70 ± 3% (P < 0.01 compared to room air), 71 ± 5% (P = 0.59), and 68 ± 5% (P < 0.05) under hyperoxic condition. The SSS, SS, and IJV drained 46 ± 9%, 16 ± 4%, and 79 ± 1% of whole-brain blood flow, respectively, and this flow distribution did not change under hypercapnic condition (P > 0.5).

conclusionThe results found in this study provide insight into the venous oxygenation and venous flow distribution and its heterogeneity among different venous structures. LEVEL OF EVIDENCE: 1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2018;47:1091-1098.

Indexed as

AdultBrain MappingCerebral VeinsCerebrovascular CirculationFemaleHumansImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleReference ValuesReproducibility of ResultsYoung Adultbrain MRIcerebral blood flowcerebral hemodynamicsvenous flow distributionvenous oxygenationvenous oxygenation distribution

Identifiers

PMID28791759
PMCPMC5807233
OpenAlexW2742648087

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.