ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2017
Bone Marrow Fat Changes After Gastric Bypass Surgery Are Associated With Loss of Bone Mass.
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Trends in insulin-like growth factor-1 levels after bariatric surgery: a systematic review and meta-analysis.International journal of obesity (2005) · 2022Pooled it
- Effects of Exercise on Bone Marrow Adipose Tissue in Children With Overweight/Obesity: Role of Liver Fat.The Journal of clinical endocrinology and metabolism · 2025Trial
- Changes in Bone Marrow Fat upon Dietary-Induced Weight Loss.Nutrients · 2020Trial
- Association of habitual diet and bone marrow adipose tissue - magnetic resonance imaging in a population-based sample.Nutrition journal · 2026Article
- MRI andEndocrine oncology (Bristol, England) · 2026Article
- Function and Regulation of Bone Marrow Adipose Tissue in Health and Disease: State of the Field and Clinical Considerations.Comprehensive Physiology · 2024Review
- The Impact of Interventional Weight Loss on Bone Marrow Adipose Tissue in People Living with Obesity and Its Connection to Bone Metabolism.Nutrients · 2023Review
- The risk of osteoporotic fracture in gastric cancer survivors: total gastrectomy versus subtotal gastrectomy versus endoscopic treatment.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2023Article
- Bariatric Surgery Negatively Impacts Bone Health in Adolescents.Radiology · 2023Article
- Energy Balance and Bone Health: a Nutrient Availability Perspective.Current osteoporosis reports · 2023Review
- Risk Factors Associated with Bone Marrow Adiposity Deposition in Postmenopausal Women in the CASH China Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Article
- Bone marrow adipose tissue composition and glycemic improvements after gastric bypass surgery.Bone reports · 2022Article
- Dietary Saturated Fat and Bone Health in Young Adults: The Young Finns Cohort.Calcified tissue international · 2022Observational
- Bone marrow adiposity in diabetes and clinical interventions.Current opinion in endocrinology, diabetes, and obesity · 2022Review
- Development of a novel method to measure bone marrow fat fraction in older women using high-resolution peripheral quantitative computed tomography.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Article
- Bone marrow adipose tissue in metabolic health.Trends in endocrinology and metabolism: TEM · 2022Review
- Skeletal muscle mitoribosomal defects are linked to low bone mass caused by bone marrow inflammation in male mice.Journal of cachexia, sarcopenia and muscle · 2022Article
- Bone Response to Weight Loss Following Bariatric Surgery.Frontiers in endocrinology · 2022Review
- Adipocyte-Cancer Cell Interactions in the Bone Microenvironment.Frontiers in endocrinology · 2022Review
- Long Bone Mineral Loss, Bone Microstructural Changes and Oxidative Stress AfterFrontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
Abstract
Bone marrow fat is a unique fat depot that may regulate bone metabolism. Marrow fat is increased in states of low bone mass, severe underweight, and diabetes. However, longitudinal effects of weight loss and improved glucose homeostasis on marrow fat are unclear, as is the relationship between marrow fat and bone mineral density (BMD) changes. We hypothesized that after Roux-en-Y gastric bypass (RYGB) surgery, marrow fat changes are associated with BMD loss. We enrolled 30 obese women, stratified by diabetes status. Before and 6 months after RYGB, we measured BMD by dual-energy X-ray absorptiometry (DXA) and quantitative computed tomography (QCT) and vertebral marrow fat content by magnetic resonance spectroscopy. At baseline, those with higher marrow fat had lower BMD. Postoperatively, total body fat declined dramatically in all participants. Effects of RYGB on marrow fat differed by diabetes status (p = 0.03). Nondiabetic women showed no significant mean change in marrow fat (+1.8%, 95% confidence interval [CI] -1.8% to +5.4%, p = 0.29), although those who lost more total body fat were more likely to have marrow fat increases (r = -0.70, p = 0.01). In contrast, diabetic women demonstrated a mean marrow fat change of -6.5% (95% CI -13.1% to 0%, p = 0.05). Overall, those with greater improvements in hemoglobin A1c had decreases in marrow fat (r = 0.50, p = 0.01). Increases in IGF-1, a potential mediator of the marrow fat-bone relationship, were associated with marrow fat declines (r = -0.40, p = 0.05). Spinal volumetric BMD decreased by 6.4% ± 5.9% (p < 0.01), and femoral neck areal BMD decreased by 4.3% ± 4.1% (p < 0.01). Marrow fat and BMD changes were negatively associated, such that those with marrow fat increases had more BMD loss at both spine (r = -0.58, p < 0.01) and femoral neck (r = -0.49, p = 0.01), independent of age and menopause. Our findings suggest that glucose metabolism and weight loss may influence marrow fat behavior, and marrow fat may be a determinant of bone metabolism. © 2017 American Society for Bone and Mineral Research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.