ReviewJournal of neurochemistry2017
The medial habenula and interpeduncular nucleus circuitry is critical in addiction, anxiety, and mood regulation.
Review in Journal of neurochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 1 synthesis or guideline pooled it, 217 citations in OpenAlex.
- Deep Brain Stimulation of the Habenula: Systematic Review of the Literature and Clinical Trial Registries.Frontiers in psychiatry · 2021Pooled it
- Predictive biomarkers of placebo response in patients with cancer: an exploratory analysis of the ABCD randomized clinical trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Asymmetrical modulation of fear expression via GABAProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Bed Nucleus of the Stria Terminalis PACAP Signaling in the Dorsal Medial Habenula Mediates Depression-Related Behavioral Responses After Chronic Stress.Biological psychiatry · 2026Article
- Transcriptional Response to Chronic Long-Access Fentanyl Self-Administration in Rat Habenula and Amygdala.Addiction biology · 2026Article
- Protocol for monitoring neurotransmitter release upon projection-specific activation in mouse dorsal raphe nucleus via in vivo fiber photometry.STAR protocols · 2026Article
- Mu Opioid Receptor mRNA and Protein Localization Across the Rat and Mouse Habenula.The Journal of comparative neurology · 2026Article
- Postnatal expression of the transcription factor Ebf2 in motivation, reward, and pain-related circuits of the mouse brain.Frontiers in neuroanatomy · 2026Article
- Heparan sulfate endosulfatases, Sulf1 and Sulf2, are required for formation of the medial habenula-interpeduncular nucleus circuit.Frontiers in neuroanatomy · 2026Article
- Affective tactile stimulation ameliorates chronic pain and comorbid anxiety by modulating hippocampal CA1 oscillations and functional connectivity.Frontiers in molecular neuroscience · 2026Article
- Mu opioid receptor mRNA and protein localization across the rat and mouse habenula.bioRxiv : the preprint server for biology · 2025Article
- Nicotinic Receptors in the Medial Habenula to Interpeduncular Nucleus Pathway: Modulators of Reward, Aversion and Emotion.The European journal of neuroscience · 2025Review
- Article
- Interpeduncular GABAergic neuron function controls threat processing and innate defensive adaptive learning.Molecular psychiatry · 2025Article
- Trans-Synaptic Virus Tracing Reveals Reciprocal Connections of the Interpeduncular Nucleus With the Mood, Exteroceptive, Interoceptive, and Motor Control Systems.The Journal of comparative neurology · 2025Article
- Novel neurotherapeutic targets for substance use disorders: Neuroplasticity, neuroinflammation, gasotransmitters and non-canonical organ systems.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Review
- Complex opioid driven modulation of glutamatergic and cholinergic neurotransmission in a GABAergic brain nucleus associated with emotion, reward and addiction.bioRxiv : the preprint server for biology · 2025Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Mu-opioid receptor activation potentiates excitatory transmission at the habenulo-peduncular synapse.Cell reports · 2025Article
- Distribution of mRNA for the exocytotic calcium sensor, synaptotagmin 9, in mouse brain.IBRO neuroscience reports · 2025Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Abstinence from chronic use of addictive drugs triggers an aversive withdrawal syndrome that compels relapse and deters abstinence. Many features of this syndrome are common across multiple drugs, involving both affective and physical symptoms. Some of the network signaling underlying withdrawal symptoms overlaps with activity that is associated with aversive mood states, including anxiety and depression. Given these shared features, it is not surprising that a particular circuit, the dorsal diencephalic conduction system, and the medial habenula (MHb) and interpeduncular nucleus (IPN), in particular, have been identified as critical to the emergence of aversive states that arise both as a result and, independently, of drug addiction. As the features of this circuit continue to be characterized, the MHb-IPN axis is emerging as a viable target for therapeutics to aid in the treatment of addiction to multiple drugs of abuse as well as mood-associated disorders. This is an article for the special issue XVth International Symposium on Cholinergic Mechanisms.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.